The Risk of Exacerbation of Myasthenia Gravis After COVID-19 Omicron Infection

被引：0

作者：

Zhang, Nana ^{[1
]}

Wang, Ziya ^{[1
]}

Sun, Dongren ^{[1
]}

Chen, Hongxi ^{[1
]}

Zhou, Hongyu ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China

来源：

BRAIN AND BEHAVIOR | 2024年 / 14卷 / 10期

关键词：

COVID-19; myasthenia gravis; Omicron; SARS-COV-2; IMPACT; VACCINATION; DISEASE;

D O I：

10.1002/brb3.70074

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Objective: The aim of this study is to ascertain whether COVID-19 Omicron infection is associated with exacerbations in these myasthenia gravis (MG) patients. Result: In total, 289 MG patients (comprising 60% females, with an average age of 46 +/- 15 years) were enrolled. A total of 80.9% of MG patients reported a COVID-19 infection, with the majority experiencing a benign course (88%). MG patients who experienced COVID-19 infection demonstrated a higher likelihood of MG exacerbation, compared to those without the infection (18.8% vs. 7.3%, p = 0.039). In the survival analysis, after adjusting for confounding factors, the hazard ratio (HR) for exacerbation post-infection was found to be 3.38 (95% CI 1.20-9.53, p = 0.021). Compared to the exacerbation rates observed in JTA21, an increase was noted in DTM23 among COVID-19-infected MG patients (4.4% vs. 17.2%, p < 0.001). Conclusion: The COVID-19 is the risk of MG exacerbation.

引用

页数：9

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