A comprehensive review of the roles of T-cell immunity in preeclampsia

被引：1
作者：
Peng, Xu [1 ]
Chinwe Oluchi-Amaka, Ibeh [1 ]
Kwak-Kim, Joanne [2 ,3 ]
Yang, Xiuhua [1 ]
机构：
[1] China Med Univ, Hosp 1, Dept Obstet, Shenyang, Peoples R China
[2] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Clin Sci Dept, Reprod Med & Immunol Obstet & Gynecol, N Chicago, IL 60064 USA
[3] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Clin Immunol Lab, Fdn Sci & Humanities Microbiol & Immunol, N Chicago, IL 60064 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2025年 / 16卷
关键词：
pregnancy; preeclampsia; T cells; Treg cells; Th17; cells; BLOOD MONONUCLEAR-CELLS; NECROSIS-FACTOR-ALPHA; RECURRENT PREGNANCY LOSS; HUMAN CORD BLOOD; REGULATORY T; PERIPHERAL-BLOOD; DENDRITIC CELLS; TH17; CELLS; HLA-G; TRANSCRIPTION FACTORS;
D O I：
10.3389/fimmu.2025.1476123
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Preeclampsia (PE) is an obstetrical disorder that occurs after the 20th week of gestation. It is recognized as one of the "Great Obstetrical Syndromes" and principally contributes to maternal morbidity and mortality. PE has been associated with a range of immune disorders, including a preponderance of T helper (Th) 1 over Th2 cells and imbalanced levels of Th17 and T regulatory cells (Tregs). During pregnancy, T cells safeguard the placenta against immune rejection and aid embryo implantation while involved in pregnancy complications, such as PE. Promoting alloantigen-specific Treg cells is a potential preventive and therapeutic strategy for PE. However, ensuring the safety of mothers and infants is of the utmost importance since the risk-benefit ratio of reproductive and obstetric conditions differs significantly from that of immune diseases that pose a life-threatening risk. In this review, we systematically summarize the roles of T-cell immunity in the peripheral blood, reproductive tissues, and at the maternal-fetal interface of PE patients. Furthermore, the recent therapeutic approaches centered on targeting T cell immunity in PE are critically appraised.
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页数：18
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