NAC transcription factors as biological macromolecules responded to abiotic stress: A comprehensive review

NAC transcription factors (NAC TFs) represent a large and vital family of transcription factors in the plant kingdom, playing a central role in regulating plant growth, developmental processes, and responses to abiotic stresses. As key regulators, NAC TFs fine-tune the expression of downstream genes, thereby actively contributing to the adaptation of crops to various abiotic stresses. The functions of NAC TFs are controlled by several complex signaling pathways, including those involving phytohormones (such as abscisic acid (ABA) and ethylene (ET)), reactive oxygen species (ROS), and mitogen-activated protein kinases (MAPKs). This review highlights recent advances in the biological functions and signaling pathways of NAC TFs in crops under abiotic stress conditions, such as drought, salinity, and extreme temperatures. It also offers prospects for further exploration of the complex mechanisms by which NAC TFs operate within signaling networks, with the aim of developing food crops with enhanced physiological traits.