Acid-Responsive Bacteria-Targeted Zinc-Porphyrin Based Sonosensitizer with Enhancing Antibacterial Efficacy and Biofilm Eradication for Infected Wounds Healing

被引：0
作者：
Zhao, Xingjun [1 ]
Li, Jiaxin [1 ]
Zhang, Peng [2 ]
Xiao, Chunsheng [2 ]
Chen, Li [1 ]
机构：
[1] Northeast Normal Univ, Dept Chem, Changchun 130024, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China
来源：
ADVANCED HEALTHCARE MATERIALS | 2025年
基金：
中国国家自然科学基金;
关键词：
antibiofilm; metal-organic frameworks; sonodynamic therapy; targeted antibacteria; wounds healing; zinc-porphyrin; SONODYNAMIC THERAPY; ORGANIC FRAMEWORK; PENETRATION; RESISTANCE;
D O I：
10.1002/adhm.202404643
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Diseases caused by bacterial infections place a significant burden on global public health. Sonodynamic therapy (SDT), as an emerging antibacterial treatment, faces clinical challenges due to the non-polar nature of most sonosensitizers. To address this, an acid-responsive zinc-porphyrin-based sonosensitizer (Zn-TCPP) is developed via a simple thermal reaction, which is then coated with phenylboronic acid-modified hyaluronic acid (B-HA), to fabricate B-HA@Zn-TCPP. While in the mildly acidic microenvironment mimicking an infected wound site, the released B-HA@Zn-TCPP achieves effective SDT activity. The disruption of the bacterial membrane and the levels of intracellular reactive oxygen species (ROS) verified that the inhibition rate can reach 99% within 5 min, without any development of resistance after 15 consecutive generations of culture. Additionally, under ultrasound (US) -mediated cavitation, B-HA@Zn-TCPP exhibits excellent penetration into biofilms, achieving a 90.04% bactericidal rate for bacteria within biofilms. In vivo studies further demonstrated that B-HA@Zn-TCPP can effectively accelerate the healing of bacterial infected wounds with a wound healing rate of 98.65% within 9 days. Therefore, B-HA@Zn-TCPP as a novel sonosensitizer offers a viable strategy to overcome the limitations of traditional sonosensitizers for the bacterial wound infections.
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页数：17
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