The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

被引：0

作者：

Martin-Castano, Benita ^{[1
,2
]}

Diez-Echave, Patricia ^{[2
,3
]}

Garcia-Garcia, Jorge ^{[2
,3
,4
]}

Hidalgo-Garcia, Laura ^{[2
,3
]}

Ruiz-Malagon, Antonio Jesus ^{[2
,3
]}

Molina-Tijeras, Jose Alberto ^{[2
,3
]}

Rodriguez-Sojo, Maria Jesus ^{[2
,3
]}

Redruello-Romero, Anais

Martinez-Zaldivar, Margarita ^{[5
]}

Mota, Emilio ^{[5
]}

Cobo, Fernando ^{[6
]}

Diaz-Villamarin, Xando ^{[7
]}

Alvarez-Estevez, Marta ^{[2
,4
,8
]}

Garcia, Federico ^{[2
,4
,8
]}

Morales-Garcia, Concepcion ^{[9
]}

Merlos, Silvia ^{[9
]}

Garcia-Flores, Paula ^{[9
]}

Colmenero-Ruiz, Manuel ^{[2
,10
]}

Hernandez-Quero, Jose ^{[2
,11
]}

Nunez, Maria ^{[2
,12
,13
]}

Rodriguez-Cabezas, Maria Elena ^{[2
,3
]}

Carazo, Angel ^{[2
,4
]}

Martin, Javier ^{[14
]}

Moron, Rocio ^{[2
,12
]}

Nogales, Alba Rodriguez ^{[2
,3
]}

Galvez, Julio ^{[2
,3
,15
]}

机构：

[1] Ctr Salud Las Gabias, Dist Granada Metropolitano, Granada, Spain

[2] Inst Invest Biosanit Granada Ibs GRANADA, Granada, Spain

[3] Univ Granada, Ctr Biomed Res CIBM, Dept Pharmacol, Granada, Spain

[4] Hosp Univ Clin San Cecilio, Serv Microbiol, Granada, Spain

[5] Ctr Salud Salvador Caballero, Dist Granada Metropolitano, Granada, Spain

[6] Hosp Univ Virgen de las Nieves, Serv Microbiol, Granada, Spain

[7] Inst Invest Biosanit, Granada, Spain

[8] Inst Salud Carlos III, CIBER Enfermedades Infecciosas CIBER INFECC, Madrid, Spain

[9] Hosp Univ Virgen de las Nieves, Resp Med Dept, Granada, Spain

[10] Hosp Univ Clin San Cecilio, Serv Med Intens, Granada, Spain

[11] Hosp Univ Clin San Cecilio, Serv Enfermedades Infecciosas, Granada, Spain

[12] Hosp Univ Clin San Cecilio, Serv Farm Hosp, Granada, Spain

[13] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBER ESP, Madrid, Spain

[14] CSIC, Inst Parasitol & Biomed Lopez Neyra, Dept Cell Biol & Immunol, Granada, Spain

[15] Inst Salud Carlos III, CIBER Enfermedades Hepat & Digest CIBER EHD, Madrid, Spain

来源：

ELIFE | 2025年 / 13卷

关键词：

SARS-CoV-2; microbiome; nasopharyngeal; Human; DYNAMICS;

D O I：

10.7554/eLife.95292; 10.7554/eLife.95292.3.sa1; 10.7554/eLife.95292.3.sa2; 10.7554/eLife.95292.3.sa3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity, and microbiota could play a key role in the infection, progression, and outcome of the disease. SARS-CoV-2 infection has been associated with nasopharyngeal and gut dysbiosis and higher abundance of opportunistic pathogens. To identify new prognostic markers for the disease, a multicentre prospective observational cohort study was carried out in COVID-19 patients divided into three cohorts based on symptomatology: mild (n = 24), moderate (n = 51), and severe/critical (n = 31). Faecal and nasopharyngeal samples were taken, and the microbiota was analysed. Linear discriminant analysis identified Mycoplasma salivarium, Prevotella dentalis, and Haemophilus parainfluenzae as biomarkers of severe COVID-19 in nasopharyngeal microbiota, while Prevotella bivia and Prevotella timonensis were defined in faecal microbiota. Additionally, a connection between faecal and nasopharyngeal microbiota was identified, with a significant ratio between P. timonensis (faeces) and P. dentalis and M. salivarium (nasopharyngeal) abundances found in critically ill patients. This ratio could serve as a novel prognostic tool for identifying severe COVID-19 cases.

引用

页数：20