Extraction of Chlorogenic Acid Using Single and Mixed Solvents

被引：0
作者：
Jeon, Hyeon Ji [1 ,2 ]
Lee, Bong-Seop [1 ,2 ]
Park, Changhyup [2 ]
机构：
[1] Kangwon Natl Univ, Dept Chem Engn, Chunchon 24341, Gangwon, South Korea
[2] Kangwon Natl Univ, Dept Integrat Engn Hydrogen Safety, Chunchon 24341, Gangwon, South Korea
来源：
MOLECULES | 2025年 / 30卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
chlorogenic acid; COSMO-SAC; Hansen solubility parameter; extraction; mixed solvents; COSMO-SAC; ACTIVITY-COEFFICIENT; SOLUBILITY PARAMETERS; MOLECULE SOLUBILITY; PHASE-EQUILIBRIUM; WATER-ETHANOL; NRTL-SAC; PREDICTION; ANTIOXIDANT; COFFEE;
D O I：
10.3390/molecules30030481
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chlorogenic acid, which is extracted from a wide range of natural sources, is attracting the attention of many researchers in the pharmaceutical and biomedical fields due to its various positive effects, such as such as anti-inflammatory and antibacterial properties. Considering the effects of economics and solvent toxicity, water, ethanol, and their mixtures were selected as the solvents for extracting chlorogenic acid at various temperatures (298 similar to 318 K) and over a whole range of concentrations. The solubility of chlorogenic acid increased with temperature regardless of the solvents, and the solubility was higher in pure ethanol than in pure water. The solubility of chlorogenic acid in mixed solvents exhibited a gradual rise as the water content increased, reaching a maximum at a specific water weight fraction. These trends were well predicted by the COSMO-SAC model and Hansen solubility parameter method. By comparing the sigma-profile, it was confirmed that the maximum solubility in mixed solvent comes from the similarity of sigma-profiles between chlorogenic acid and mixed solvent which represents the surface charge density of the molecule.
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页数：14
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