Cardio-Oncology and Heart Failure: a Scientific Statement From the Heart Failure Society of America

被引：7

作者：

Bloom, Michelle weisfelner ^{[1
,8
]}

Vo, Jacqueline b. ^{[2
]}

Rodgers, Jo e. ^{[3
]}

Ferrari, Alana m. ^{[4
]}

Nohria, Anju ^{[5
]}

Deswal, Anita ^{[6
]}

Cheng, Richard k. ^{[7
]}

Kittleson, Michelle m.

Upshaw, Jenica n. ^{[9
]}

Palaskas, Nicolas ^{[10
]}

Blaes, Anne ^{[11
]}

Brown, Sherry-ann ^{[12
,13
]}

Ky, Bonnie ^{[14
,15
,16
]}

Lenihan, Daniel ^{[17
,18
]}

Maurer, Mathew s. ^{[19
]}

Fadol, Anecita ^{[20
]}

Skurka, Kerry

Cambareri, Christine ^{[21
]}

Chauhan, Cynthia

Barac, Ana ^{[22
]}

机构：

[1] NYU, Grossman Sch Med, Div Cardiol, NYU Langone Hlth, New York, NY USA

[2] NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD USA

[3] UNC, Div Pharmacotherapy & Expt Therapeut, Eshelman Sch Pharm, Chapel Hill, NC USA

[4] Univ Virginia Hlth, Div Hematol Oncol, Charlottesville, VA USA

[5] Brigham & Womens Hosp, Cardiooncol Program, Cardiol Div, Boston, MA USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Cardiol, Houston, TX USA

[7] Univ Washington, Div Cardiol, Seattle, WA USA

[8] Cedars Sinai Med Ctr, Smidt Heart Inst, Dept Cardiol, Los Angeles, CA USA

[9] Tufts Med Ctr, Div Cardiol, Boston, MA USA

[10] Univ Texas MD Anderson Canc Ctr, Dept Cardiol, Div Internal Med, Houston, TX USA

[11] Univ Minnesota, Div Hematol Oncol Transplantat, Minneapolis, MN USA

[12] Mayo Clin, Dept Med, Rochester, MN 55905 USA

[13] Mayo Clin, Rochester, MN USA

[14] Univ Penn, Perelman Sch Med, Div Cardiol, Philadelphia, PA USA

[15] Univ Penn, Thalheimer Ctr Cardiooncol, Abramson Canc Ctr, Philadelphia, PA USA

[16] Univ Penn, Perelman Sch Med, Div Cardiovasc Med, Philadelphia, PA USA

[17] St Francis Healthcare, Cape Girardeau, MO USA

[18] Int Cardiooncol Soc, Tampa, FL USA

[19] Columbia Univ, Irving Med Ctr, Div Cardiol, New York, NY USA

[20] MD Anderson Canc Ctr, Houston, TX USA

[21] Hosp Univ Penn, Abramson Canc Ctr, Philadelphia, PA USA

[22] Inova Schar Canc, Inova Schar Heart & Vasc, Dept Cardiol, Falls Church, VA USA

来源：

JOURNAL OF CARDIAC FAILURE | 2025年 / 31卷 / 02期

关键词：

Heart failure; cancer; cardiotoxicity; cardio-oncology; cancer treatment-related cardiac dysfunction; car-diomyopathy; heart failure with reduced ejection fraction; heart failure with preserved ejection fraction; bone marrow/ stem cell transplant; pulmonary hypertension; mechanical circulatory support; myocarditis; stress cardiomyopathy; cancer survivorship; pregnancy; palliative care; multidisciplinary care; health disparities; and social determinants; PRESERVED EJECTION FRACTION; PEGYLATED LIPOSOMAL DOXORUBICIN; LONG-TERM SURVIVORS; ANGIOTENSIN SYSTEM INHIBITORS; SOLID-ORGAN TRANSPLANTATION; CONSENSUS DECISION PATHWAY; VENTRICULAR ASSIST DEVICES; CYTOKINE RELEASE SYNDROME; EARLY BREAST-CANCER; 7-YEAR FOLLOW-UP;

D O I：

10.1016/j.cardfail.2024.08.045

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure and cancer remain 2 of the leading causes of morbidity and mortality, and the 2 disease entities are linked in a complex manner. Patients with cancer are at increased risk of cardiovascular complications related to the cancer therapies. The presence of cardiomyopathy or heart failure in a patient with new cancer diagnosis portends a high risk for adverse oncology and cardiovascular outcomes. With the rapid growth of cancer therapies, many of which interfere with cardiovascular homeostasis, heart failure practitioners need to be familiar with prevention, risk stratification, diagnosis, and management strategies in cardio-oncology. This Heart Failure Society of America statement addresses the complexities of heart failure care among patients with active cancer diagnoses and cancer survivors. Risk stratification, monitoring and management of cardiotoxicity are presented across stages A through D heart failure, with focused discussion on heart failure with preserved ejection fraction and special populations, such as survivors of childhood and young-adulthood cancers. We provide an overview of the shared risk factors between cancer and heart failure, highlighting heart failure as a form of cardiotoxicity associated with many different cancer therapeutics. Finally, we discuss disparities in the care of patients with cancer and cardiac disease and present a framework for a multidisciplinary-team approach and critical collaboration among heart failure, oncology, palliative care, pharmacy, and nursing teams in the management of these complex patients. (J Cardiac Fail 2025;31:415-455)

引用

页码：415 / 455

页数：41

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