An Internet Mantram Repetition Program to Promote Well-being in Breast Cancer Survivors: A Feasibility Randomized Controlled Trial

被引：0

作者：

Hulett, Jennifer M. ^{[1
]}

Cheng, An-Lin ^{[2
]}

Bormann, Jill E. ^{[3
]}

Anbari, Allison B. ^{[1
]}

Armer, Jane M. ^{[1
]}

Hartman, Brooke M. ^{[1
]}

Bettencourt, B. Ann ^{[1
]}

Sherwin, LeeAnne B. ^{[1
]}

Sperling, Edie L. ^{[1
,4
]}

Narkthong, Natsayakarn ^{[1
]}

Reinero, Carol ^{[1
]}

Rindt, Hans ^{[1
]}

Schreiber, Kathy ^{[1
]}

Peterson, Lindsay L. ^{[5
]}

Albright, Emily ^{[1
]}

机构：

[1] Univ Missouri, Columbia, MO USA

[2] Univ Missouri, Kansas City, MO USA

[3] Univ San Diego, San Diego, CA USA

[4] Western Univ Hlth Sci, Pomona, CA USA

[5] Washington Univ, St Louis, MO USA

来源：

INTEGRATIVE CANCER THERAPIES | 2024年 / 23卷

关键词：

breast cancer; immune; mantram repetition program; psychological; spiritual; stress; STRESS; MEDITATION; OUTCOMES; WOMEN; INTERVENTION; RECURRENCE; VETERANS; THERAPY; ADULTS; HIV;

D O I：

10.1177/15347354241290504

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: The primary objective of this study was to assess the feasibility of a 6-week internet-delivered Mantram Repetition Program (MRP) for women recently treated for breast cancer. A secondary objective explored changes in perceived stress, psycho-spiritual measures, and cytokines in the treatment group compared to a waitlist. Methods: A feasibility study (ORBIT model Phase IIa) with a randomized controlled trial pilot was conducted. Eligible women recently treated for breast cancer were randomized to the treatment group (n = 14) or a waitlist group (n = 12) and participated for 12 weeks. During weeks 1-6, the treatment group received the MRP intervention while the waitlisted group was inactive. During weeks 7-12, the treatment group was inactive while the waitlisted group received the MRP intervention. The primary outcomes were feasibility and acceptability of the internet-delivered MRP intervention protocol. Participants completed pre and post-intervention psycho-spiritual health assessments. A subset of participants provided serum for cytokine analyses at enrollment and week 6, coinciding with the period in which the treatment group receiving the MRP intervention. Results: Overall study attrition was 19.2%. MRP adherence for both groups was 86% at post-intervention and 90% in the treatment group at 6-week follow-up. Pre-to-post-intervention analyses pooling both groups' data demonstrated decreased perceived stress (p = .045) and increased spiritual well-being (p =.004). IFN-gamma and IL-17A were increased in the waitlisted group and decreased in the treatment group (p = 0.048). Conclusion: Feasibility of a 6-week, internet-delivered MRP intervention for breast cancer survivors was established. Psycho-spiritual variables and serum cytokines are suitable clinical outcome measures for future MRP studies with breast cancer survivors. Data suggest MRP may reduce perceived stress and support spiritual well-being in women with breast cancer; however, additional studies are needed.

引用

页数：15

共 55 条

[1] BEHAVIORALLY CONDITIONED IMMUNOSUPPRESSION [J].