Characterization of a novel lytic phage against methicillin resistance Staphylococcus aureus in Hainan island

被引：0
作者：
Li, Yanmei [1 ]
Zhang, Yue [1 ]
Li, Anyang [1 ]
Zhang, Ting [1 ]
Yi, Jiling [2 ,3 ]
Zhang, Nan [1 ]
Kang, Xun [1 ]
Liu, Wei [1 ]
Tian, Shen [1 ]
Xia, Qianfeng [1 ]
机构：
[1] Hainan Med Univ, Sch Trop Med, Haikou 571199, Peoples R China
[2] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Resource Chem, Minist Educ, Haikou 571158, Peoples R China
[3] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Plant Chem Hainan Prov, Haikou 571158, Hainan, Peoples R China
来源：
VIROLOGY | 2024年 / 600卷
关键词：
Bacteriophage; Rosenblumvirus; Methicillin resistance Staphylococcus aureus; VANCOMYCIN; SEQUENCE; GROWTH;
D O I：
10.1016/j.virol.2024.110264
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Methicillin resistance Staphylococcus aureus (MRSA) is currently threatening global public health, and a similar issue was encountered in Hainan. For establishing a promising alternative therapeutic option, a phage with the capacity of lysing 18 out of 35 MRSA clinical isolates was recovered from domestic natural sources, which was termed as vB_SauP_L1 due to its morphology and genomic similarity with Rountreeviridae. Satisfactory proliferation rate and environmental tolerance were demonstrated by subsequent infectious properties tests and stability assessments. Sequencing revealed that its genome consisted of a linear double-stranded DNA of 17,114 bp, in which neither virulent nor resistant gene was detected, indicating its potential in MRSA prevention and treatment.
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页数：8
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