Targeting the BMI1-Noxa axis by Dioscin induces apoptosis in oral squamous cell carcinoma cells

被引:0
作者
Fang, Jinglin [1 ,2 ]
Wang, Ruirui [3 ]
Li, Xiaoying [3 ]
Wang, Xiaocong [1 ,2 ]
Gong, Lingling [1 ,2 ]
Lou, An [1 ,2 ]
Lu, Jie [1 ,2 ]
Zhang, Xiaoyue [2 ]
Zhao, Qin [2 ]
Yu, Xinfang [5 ,6 ,7 ]
Zhou, Qiling [4 ]
Li, Ming [1 ,2 ]
机构
[1] Hunan Univ Chinese Med, Sch Stomatol, Changsha 410208, Hunan, Peoples R China
[2] Changsha Stomatol Hosp, Changsha 410004, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Hosp 3, Dept Radiol, Changsha 410013, Hunan, Peoples R China
[4] Changsha Hlth Vocat Coll, Changsha 410600, Hunan, Peoples R China
[5] Cent South Univ, Xiangya Hosp, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha 410008, Hunan, Peoples R China
[6] Cent South Univ, Canc Res Inst, Key Lab Carcinogenesis Natl Hlth Commiss, Changsha 410008, Hunan, Peoples R China
[7] Cent South Univ, Sch Basic Med Sci, Xiangya Sch Med, Changsha 410008, Hunan, Peoples R China
关键词
Oral squamous cell carcinoma; Noxa; BMI1; Dioscin; LUNG-CANCER; MESENCHYMAL TRANSITION; TELOMERASE ACTIVITY; BMI-1; EXPRESSION; NOXA; MEL-18; PROGRESSION; PROTEINS; SURVIVAL; MEDIATOR;
D O I
10.7150/jca.100631
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Dioscin is a natural plant-derived steroidal saponin that exerts antitumor effects in multiple cancers. It is widely involved in multiple apoptotic pathways and exerts its anti-tumor effects. In this study, we discovered that Dioscin treatment increased the expression of Noxa, thereby inducing the apoptosis of OSCC cells. Previous reports indicate that dysfunction of the BMI1-Noxa axis is frequently observed in multiple cancers. Our study revealed that Dioscin upregulates Noxa by impairing the protein expression of BMI1 in OSCC cells. Dioscin promotes the ubiquitination of BMI1 and facilitates its degradation, leading to upregulation of Noxa expression at the mRNA level and activation of apoptosis. Additionally, Dioscin exhibited potent tumor suppression in xenograft tumor models. In conclusion, our research provides new insights and strategies for inhibiting OSCC cells by investigating the ant-tumor mechanism of the natural compound Dioscin.
引用
收藏
页码:110 / 121
页数:12
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