The impact of circadian rhythms on retinal immunity

被引：0

作者：

Ren, He ^{[1
]}

Yuan, Yilin ^{[1
]}

Zhang, Danlei ^{[1
]}

Xing, Yiqiao ^{[1
]}

Chen, Zhen ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Eye Ctr, Wuhan, Peoples R China

来源：

CHRONOBIOLOGY INTERNATIONAL | 2025年 / 42卷 / 02期

关键词：

Circadian rhythm; ocular immunity; retinal pigment epithelium; microglia; retinal diseases; NF-KAPPA-B; REV-ERB; PHOTORECEPTOR CELLS; MELATONIN RECEPTORS; DOPAMINE RELEASE; MAMMALIAN RETINA; EPITHELIAL-CELLS; GANGLION-CELLS; CLOCK GENES; LIGHT;

D O I：

10.1080/07420528.2025.2460675

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The eye is an immune-protected organ, which is driven by factors such as cytokines, chemicals, light, and mechanical stimuli. The circadian clock is an intrinsic timing mechanism that influences the immune activities, such as immune cell count and activity, as well as inflammatory responses. Recent studies have demonstrated that the eye also possesses an intrinsic circadian rhythm, and this rhythmic regulation participates in ocular immune modulation. In this review, we discuss the immunoregulatory mechanisms of the circadian clock within the eye, and reveal new perspectives for the prevention and treatment of ocular diseases.

引用

页码：198 / 212

页数：15

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