Triglyceride-glucose index (TyG) as a novel biomarker in the era of cardiometabolic medicine

被引：11

作者：

Avagimyan, Ashot ^{[1
]}

Pogosova, Nana ^{[2
,3
]}

Fogacci, Federica ^{[4
]}

Aghajanova, Elena ^{[5
,6
]}

Djndoyan, Zinaida ^{[7
,8
]}

Patoulias, Dimitrios ^{[9
]}

Lo Sasso, Lorenzo ^{[10
]}

Bernardi, Marco ^{[11
]}

Faggiano, Andrea ^{[12
,13
]}

Mohammadifard, Noushin ^{[14
]}

Neglia, Danilo ^{[15
]}

Carugo, Stefano ^{[12
,13
]}

Cicero, Arrigo ^{[16
,17
]}

Rizzo, Manfredi ^{[18
,19
]}

Biondi-Zoccai, Giuseppe ^{[11
,20
]}

De Caterina, Raffaele ^{[21
]}

Sarrafzadegan, Nizal ^{[22
,23
]}

机构：

[1] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Esfahan, Iran

[2] Moscow MV Lomonosov State Univ, Assessment Ctr LASPI, Moscow, Russia

[3] PeoplesFriendship Univ Russia, RUDN Univ, Inst Med, Moscow, Russia

[4] Univ Bologna, Atherosclerosis & Metab Disorders Res Unit, Bologna, Italy

[5] Yerevan State Med Univ, Endocrinol Dept, Mikaelyan Univ Clin, Yerevan, Armenia

[6] Yerevan State Med Univ, Muratsan Univ Clin, Endocrinol Unit, Yerevan, Armenia

[7] Yerevan State Med Univ, Mikaelyan Univ Clin, Internal Dis Propaedeut Dept, Yerevan, Armenia

[8] Yerevan State Med Univ, Mikaelyan Univ Clin, Internal Dis Unit, Yerevan, Armenia

[9] Aristotle Univ Thessaloniki, Gen Hosp Hippokrat, Outpatient Dept Cardiometab Med, Dept Cardiol 2, Thessaloniki, Greece

[10] Univ Cattolica Sacro Cuore, Rome, Italy

[11] Sapienza Univ Rome, Dept Med & Surg Sci & Biotechnol, Latina, Italy

[12] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Cardiothorac Vasc Dis, Milan, Italy

[13] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[14] Isfahan Univ Med Sci, Cardiovasc Res Inst, WHO Collaborat Ctr, Nutr Dept, Esfahan, Iran

[15] Fdn CNR Reg Toscana Gabriele Monasterio, Cardiovasc Dept, CNR Res Area, Pisa, Italy

[16] Alma Mater Studiorum Univ Bologna, Med & Surg Sci Dept, Hypertens & Cardiovasc Risk Res Unit, Bologna, Italy

[17] IRCCS Policlin S Orsola Malpighi Bologna, Cardiovasc Med Unit, Bologna, Italy

[18] Univ Palermo, Sch Med, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties Promise, I-90100 Palermo, Italy

[19] Mohammed Bin Rashid Univ Med & Hlth Sci MBRU, Dubai, U Arab Emirates

[20] GVM Care & Res, Maria Cecilia Hosp, Cotignola, Italy

[21] Univ Pisa, Dept Neuroradiol, I-56126 Pisa, Italy

[22] Isfahan Univ Med Sci, Dept Biostat, Esfahan, Iran

[23] Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC, Canada

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2025年 / 418卷

关键词：

Cardiodiabetology; Cardiovascular risk; Glucose; Triglycerides; Triglyceride-glucose index; TyG; ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; HEART-FAILURE; RISK; PATHOPHYSIOLOGY; PREVALENCE; OVERWEIGHT; IMMUNITY; OBESITY;

D O I：

10.1016/j.ijcard.2024.132663

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the period of increasing prevalence of metabolic disorders such as obesity and diabetes, healthcare professionals are facing significant challenges. Therefore, an accurate global assessment of insulin resistance is of utmost importance. Current medical research is focused on identifying an easily accessible and reproducible gold-standard surrogate marker for insulin resistance. Ideally, such a marker would enable healthcare providers to predict the risk of type 2 diabetes and cardiovascular diseases. The triglyceride-glucose index (TyG) is a promising marker for preventive cardiology and cardiometabolic medicine. This narrative review article aims to provide a comprehensive evaluation of the credibility of TyG as a surrogate marker of insulin resistance among patients at different stages across the cardiometabolic continuum. This assessment fully complies with evidence-based medicine and offers valuable insight into the clinical utility of TyG.

引用

页数：11

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