The Role of Non-Coding RNAs in Regulating Cachexia Muscle Atrophy

被引：2

作者：

Chen, Guoming ^{[1
]}

Zou, Jiayi ^{[2
]}

He, Qianhua ^{[2
]}

Xia, Shuyi ^{[3
]}

Xiao, Qili ^{[4
]}

Du, Ruoxi ^{[5
]}

Zhou, Shengmei ^{[4
]}

Zhang, Cheng ^{[1
]}

Wang, Ning ^{[1
]}

Feng, Yibin ^{[1
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Hong Kong, Peoples R China

[2] Guangzhou Univ Chinese Med, Clin Med Coll 1, Guangzhou 510405, Peoples R China

[3] Guangzhou Univ Chinese Med, Clin Med Coll 5, Guangzhou 510405, Peoples R China

[4] Guangzhou Univ Chinese Med, Clin Med Coll 2, Guangzhou 510405, Peoples R China

[5] Guangzhou Univ Chinese Med, Clin Med Coll 8, Guangzhou 510405, Peoples R China

来源：

CELLS | 2024年 / 13卷 / 19期

关键词：

muscle atrophy; cachexia; non-coding RNAs; microRNAs; lncRNAs; circRNAs; SATELLITE CELL-PROLIFERATION; SKELETAL-MUSCLE; CANCER CACHEXIA; DOWN-REGULATION; TNF-ALPHA; DIFFERENTIATION; MICRORNAS; ACTIVATION; PATHWAY; PROTEIN;

D O I：

10.3390/cells13191620

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cachexia is a late consequence of various diseases that is characterized by systemic muscle loss, with or without fat loss, leading to significant mortality. Multiple signaling pathways and molecules that increase catabolism, decrease anabolism, and interfere with muscle regeneration are activated. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play vital roles in cachexia muscle atrophy. This review mainly provides the mechanisms of specific ncRNAs to regulate muscle loss during cachexia and discusses the role of ncRNAs in cachectic biomarkers and novel therapeutic strategies that could offer new insights for clinical practice.

引用

页数：25

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