Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma

被引：7

作者：

Sun, Bo ^{[1
]}

Li, Rong ^{[1
]}

Ji, Ning ^{[5
,6
]}

Liu, Han ^{[5
,6
]}

Wang, Hongxiang ^{[1
]}

Chen, Chao ^{[1
]}

Bai, Long ^{[5
,6
]}

Su, Jiacan ^{[2
,3
,4
,5
,6
]}

Chen, Juxiang ^{[1
]}

机构：

[1] Naval Med Univ, Shanghai Changhai Hosp, Dept Neurosurg, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Orthoped, Shanghai 200092, Peoples R China

[3] Shanghai Jiao Tong Univ, Xinhua Hosp, Trauma Orthoped Ctr, Sch Med, Shanghai 200092, Peoples R China

[4] Shanghai Jiao Tong Univ, Xinhua Hosp, Inst Musculoskeletal Injury & Translat Med Organoi, Sch Med, Shanghai 200092, Peoples R China

[5] Shanghai Univ, Inst Translat Med, Shanghai 200444, Peoples R China

[6] Shanghai Univ, Natl Ctr Translat Med, SHU Branch, Shanghai 200444, Peoples R China

来源：

MATERIALS TODAY BIO | 2025年 / 30卷

基金：

中国国家自然科学基金;

关键词：

Glioblastoma; Blood brain barrier; Blood-tumor barrier; Brain targeting drug delivery system; Nanoparticles; MESENCHYMAL STEM-CELLS; GENE DELIVERY; EXTRACELLULAR VESICLES; ONCOLYTIC ADENOVIRUS; MEDIATED DELIVERY; MALIGNANT GLIOMA; PHASE-I; THERAPY; NANOPARTICLES; VIRUS;

D O I：

10.1016/j.mtbio.2025.101443

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and a poor prognosis. The blood-brain barrier (BBB) and the blood-tumor barrier (BTB) present significant obstacles to the efficacy of tumor-targeted pharmacotherapy, thereby impeding the therapeutic potential of numerous candidate drugs. Targeting delivery of adequate doses of drug across the BBB to treat GBM has become a prominent research area in recent years. This emphasis has driven the exploration and evaluation of diverse technologies for GBM pharmacotherapy, with some already undergoing clinical trials. This review provides a thorough overview of recent advancements and challenges in targeted drug delivery for GBM treatment. It specifically emphasizes systemic drug administration strategies to assess their potential and limitations in GBM treatment. Furthermore, this review highlights promising future research directions in the development of intelligent drug delivery systems aimed at overcoming current challenges and enhancing therapeutic efficacy against GBM. These advancements not only support foundational research on targeted drug delivery systems for GBM but also offer methodological approaches for future clinical applications.

引用

页数：24

共 221 条

[1] Systemic Delivery of an Adjuvant CXCR4-CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy [J].

Alghamri, Mahmoud S. ;

Banerjee, Kaushik ;

Mujeeb, Anzar A. ;

Mauser, Ava ;

Taher, Ayman ;

Thalla, Rohit ;

McClellan, Brandon L. ;

Varela, Maria L. ;

Stamatovic, Svetlana M. ;

Martinez-Revollar, Gabriela ;

V. Andjelkovic, Anuska ;

V. Gregory, Jason ;

Kadiyala, Padma ;

Calinescu, Alexandra ;

Jimenez, Jennifer A. ;

Apfelbaum, April A. ;

Lawlor, Elizabeth R. ;

Carney, Stephen ;

Comba, Andrea ;

Faisal, Syed Mohd ;

Barissi, Marcus ;

Edwards, Marta B. ;

Appelman, Henry ;

Sun, Yilun ;

Gan, Jingyao ;

Ackermann, Rose ;

Schwendeman, Anna ;

Candolfi, Marianela ;

Olin, Michael R. ;

Lahann, Joerg ;

Lowenstein, Pedro R. ;

Castro, Maria G. .

ACS NANO, 2022, 16 (06) :8729-8750

[2] Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery [J].

Almeida, Bethany ;

Nag, Okhil K. ;

Rogers, Katherine E. ;

Delehanty, James B. .

MOLECULES, 2020, 25 (23)

[3] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[4] Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers [J].

Anand, Prachi ;

O'Neil, Alison ;

Lin, Emily ;

Douglas, Trevor ;

Holford, Mande .

SCIENTIFIC REPORTS, 2015, 5

[5] Phase 2 trial of temozolomide and pegylated liposomal doxorubicin in the treatment of patients with glioblastoma multiforme following concurrent radiotherapy and chemotherapy [J].

Ananda, Sumitra ;

Nowak, Anna K. ;

Cher, Lawrence ;

Dowling, Anthony ;

Brown, Chris ;

Simes, John ;

Rosenthal, Mark A. .

JOURNAL OF CLINICAL NEUROSCIENCE, 2011, 18 (11) :1444-1448

[6] The blood-brain barrier and blood-tumour barrier in brain tumours and metastases [J].

Arvanitis, Costas D. ;

Ferraro, Gino B. ;

Jain, Rakesh K. .

NATURE REVIEWS CANCER, 2020, 20 (01) :26-41

[7] Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results [J].

Bagley, Stephen J. ;

Logun, Meghan ;

Fraietta, Joseph A. ;

Wang, Xin ;

Desai, Arati S. ;

Bagley, Linda J. ;

Nabavizadeh, Ali ;

Jarocha, Danuta ;

Martins, Rene ;

Maloney, Eileen ;

Lledo, Lester ;

Stein, Carly ;

Marshall, Amy ;

Leskowitz, Rachel ;

Jadlowsky, Julie K. ;

Christensen, Shannon ;

Oner, Bike Su ;

Plesa, Gabriela ;

Brennan, Andrea ;

Gonzalez, Vanessa ;

Chen, Fang ;

Sun, Yusha ;

Gladney, Whitney ;

Barrett, David ;

Nasrallah, MacLean P. ;

Hwang, Wei-Ting ;

Ming, Guo-Li ;

Song, Hongjun ;

Siegel, Donald L. ;

June, Carl H. ;

Hexner, Elizabeth O. ;

Binder, Zev A. ;

O'Rourke, Donald M. .

NATURE MEDICINE, 2024, 30 (05) :1320-+

[8] Chimeric Exosomes Functionalized with STING Activation for Personalized Glioblastoma Immunotherapy [J].

Bao, Peng ;

Gu, Hui-Yun ;

Ye, Jing-Jie ;

He, Jin-Lian ;

Zhong, Zhenlin ;

Yu, Ai-Xi ;

Zhang, Xian-Zheng .

ADVANCED SCIENCE, 2024, 11 (06)

[9] Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B [J].

Batista, Ana Rita ;

King, Oliver D. ;

Reardon, Christopher P. ;

Davis, Crystal ;

Shankaracharya ;

Philip, Vivek ;

Gray-Edwards, Heather ;

Aronin, Neil ;

Lutz, Cathleen ;

Landers, John ;

Sena-Esteves, Miguel .

HUMAN GENE THERAPY, 2020, 31 (1-2) :90-102

[10] RNOP-09: Pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma - a phase II study [J].

Beier, Christoph P. ;

Schmid, Christina ;

Gorlia, Thierry ;

Kleinletzenberger, Christine ;

Beier, Dagmar ;

Grauer, Oliver ;

Steinbrecher, Andreas ;

Hirschmann, Birgit ;

Brawanski, Alexander ;

Dietmaier, Christopher ;

Jauch-Worley, Tanja ;

Koelbl, Oliver ;

Pietsch, Torsten ;

Proescholdt, Martin ;

Ruemmele, Petra ;

Muigg, Armin ;

Stockhammer, Guenther ;

Hegi, Monika ;

Bogdahn, Ulrich ;

Hau, Peter .

BMC CANCER, 2009, 9 :308

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