Combined Abrocitinib and Acitretin Therapy for Darier's Disease: A Case Report

被引：0
作者：
Ye, Hui [1 ,2 ]
Chen, Weifeng [1 ,2 ]
Liu, Wenyan [1 ,2 ]
Zhu, Junhui [1 ,2 ]
Liang, Jingyao [1 ,2 ]
Zhang, Xibao [1 ,2 ]
机构：
[1] Guangzhou Med Univ, Inst Dermatol, Guangzhou 510095, Guangdong, Peoples R China
[2] Guangzhou Dermatol Hosp, Dept Dermatol, Guangzhou 510095, Guangdong, Peoples R China
来源：
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY | 2024年 / 17卷
关键词：
keratosis follicularis; Darier's disease; abrocitinib; acitretin; EXPRESSION; ATP2A2;
D O I：
10.2147/CCID.S485694
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Darier's disease (DD) is a rare chronic keratinizing skin disease characterized by dyskeratosis of epidermal cells. We report a case of DD with a medical history spanning over 20 years and recurring symptoms. Pathologically confirmed DD was treated with a combination of abrocitinib and acitretin, resulting in rapid symptom resolution within 2 weeks. No recurrence was noted in an 11- week follow-up. The mechanism may involve acitretin's inhibition of proliferation and anti-inflammation, while abrocitinib acts on IL- 6 implicated in DD pathogenesis, exerting an immunomodulatory and anti-inflammatory effect, leading to rapid symptom relief. The combination of abrocitinib and acitretin is an effective therapy for DD, offering a promising new option for refractory patients.
引用
收藏
页码：2767 / 2771
页数：5
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