Combined Abrocitinib and Acitretin Therapy for Darier's Disease: A Case Report

被引：0
作者：
Ye, Hui [1 ,2 ]
Chen, Weifeng [1 ,2 ]
Liu, Wenyan [1 ,2 ]
Zhu, Junhui [1 ,2 ]
Liang, Jingyao [1 ,2 ]
Zhang, Xibao [1 ,2 ]
机构：
[1] Guangzhou Med Univ, Inst Dermatol, Guangzhou 510095, Guangdong, Peoples R China
[2] Guangzhou Dermatol Hosp, Dept Dermatol, Guangzhou 510095, Guangdong, Peoples R China
来源：
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY | 2024年 / 17卷
关键词：
keratosis follicularis; Darier's disease; abrocitinib; acitretin; EXPRESSION; ATP2A2;
D O I：
10.2147/CCID.S485694
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Darier's disease (DD) is a rare chronic keratinizing skin disease characterized by dyskeratosis of epidermal cells. We report a case of DD with a medical history spanning over 20 years and recurring symptoms. Pathologically confirmed DD was treated with a combination of abrocitinib and acitretin, resulting in rapid symptom resolution within 2 weeks. No recurrence was noted in an 11- week follow-up. The mechanism may involve acitretin's inhibition of proliferation and anti-inflammation, while abrocitinib acts on IL- 6 implicated in DD pathogenesis, exerting an immunomodulatory and anti-inflammatory effect, leading to rapid symptom relief. The combination of abrocitinib and acitretin is an effective therapy for DD, offering a promising new option for refractory patients.
引用
收藏
页码：2767 / 2771
页数：5
相关论文
共 50 条
  • [21] Vesicular Darier's disease: a case report and review of the English literature of a rare disease variant
    Mourad, Ahmed
    Kurwa, Habib A.
    Haber, Richard M.
    [J]. SAGE OPEN MEDICAL CASE REPORTS, 2023, 11
  • [22] Clinical improvement in Darier's disease with photodynamic therapy
    Avery, Helen L.
    Hughes, Bronwyn R.
    Coley, Carol
    Cooper, Hywel L.
    [J]. AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2010, 51 (01) : 32 - 35
  • [23] Case for diagnosis. Linear Darier's disease
    Bidoia, Fernanda Del Pintor
    Massanares, Bruna Martini
    Mendes Roncada, Eduardo Vinicius
    Schaefer, Luiza Vasconcelos
    [J]. ANAIS BRASILEIROS DE DERMATOLOGIA, 2018, 93 (05) : 749 - 751
  • [24] Acitretin embryopathy: A case report
    Barbero, P
    Lotersztein, V
    Bronberg, R
    Perez, M
    Alba, L
    [J]. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2004, 70 (10) : 831 - 833
  • [25] Effective Treatment of Linear Darier's Disease with Topical Retinoids: Case Report and Review of the Literature
    Dogan, Sibel
    Karaduman, Aysen
    Erkin, Gul
    Gokoz, Ozay
    [J]. ACTA DERMATOVENEROLOGICA CROATICA, 2011, 19 (03) : 206 - 209
  • [26] Exacerbation of Darier's disease with oral lithium carbonate therapy
    Jones, SAV
    Grabczynska, SA
    Mufti, KL
    VijayasinghamHenderson, S
    Eady, RAJ
    [J]. EUROPEAN JOURNAL OF DERMATOLOGY, 1996, 6 (07) : 527 - 528
  • [27] Acitretin: Monotherapy or Combined Therapy for Hidradenitis Suppurativa?
    Tan, Marcus G.
    Shear, Neil H.
    Walsh, Scott
    Alhusayen, Raed
    [J]. JOURNAL OF CUTANEOUS MEDICINE AND SURGERY, 2017, 21 (01) : 48 - 53
  • [28] Small intestine perforation in a 58-year-old man with Darier disease after 25 months of oral acitretin therapy
    Wang, Yi-Hao
    Tsai, Dino
    [J]. DERMATOLOGICA SINICA, 2014, 32 (01) : 39 - 42
  • [29] A case of Darier's disease successfully treated with topical tacrolimus
    Rubegni, P
    Poggiali, S
    Sbano, P
    Risulo, M
    Fimiani, M
    [J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2006, 20 (01) : 84 - 87
  • [30] Cutaneous dirt-adherent disease complicated with Darier's disease, schizophrenia, and cutis verticis gyrata: A case report
    Zhu, Qing
    Guo, Shu-Jing
    Wang, Bin
    Xu, Lu-Lu
    Zhang, Guo-Qiang
    [J]. FRONTIERS IN MEDICINE, 2022, 9
12345