Disruptions of resting-state functional connectivity in post-stroke motor dysfunctions: a meta-analysis

被引：0

作者：

Zhu, Tingting ^{[1
,2
]}

Chen, Jing ^{[1
]}

Du, Yanting ^{[3
]}

Li, Tongyue ^{[1
,4
]}

Jia, Xize ^{[1
,4
]}

Lv, Yating ^{[1
,4
]}

机构：

[1] Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Affiliated Hosp, 2318 Yuhangtang Rd, Hangzhou 311121, Zhejiang, Peoples R China

[2] Maastricht Univ, Fac Psychol & Neurosci, Dept Cognit Neurosci, NL-6229 EV Maastricht, Netherlands

[3] Jiamusi Univ, Sch Informat & Elect Technol, Jiamusi 154007, Heilongjiang, Peoples R China

[4] Zhejiang Key Lab Res Assessment Cognit Impairments, Hangzhou 311121, Zhejiang, Peoples R China

来源：

BRAIN IMAGING AND BEHAVIOR | 2025年

基金：

中国国家自然科学基金;

关键词：

Stroke; Post-stroke motor dysfunctions; Resting-state fMRI; Functional connectivity; Primary motor cortex; TRANSCRANIAL MAGNETIC STIMULATION; NONINVASIVE BRAIN-STIMULATION; CORTICAL ACTIVATION; UNAFFECTED HEMISPHERE; MATTER ABNORMALITIES; FUNCTION RECOVERY; PREMOTOR CORTEX; NEURAL-NETWORKS; STROKE PATIENTS; PARETIC HAND;

D O I：

10.1007/s11682-025-00977-z

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

This study aims to unravel the consistent abnormalities in functional connectivity (FC) with the primary motor cortex (M1) for post-stroke motor dysfunctions and the dynamic shifts of FC across distinct phases (acute/subacute/chronic) following stroke onset. Eleven studies with 269 stroke patients and 257 healthy controls (HCs) were included after screening articles in PubMed, Web of Science, and Embase. Voxel-wise meta-analysis and subgroup analysis on three phases after stroke onset were applied using the anisotropic effect size-signed differential mapping toolbox. Additionally, a M1-seeded FC analysis from an independent dataset with 29 stroke patients and 40 HCs was applied to validate the results of the meta-analyses. The abnormal connectivity with M1 in patients with post-stroke motor dysfunctions extended beyond motor-related regions to non-motor domains. A consistent interhemispheric connectivity reduction between M1 and motor-related regions emerged as a hallmark, persisting across different phases after stroke onset. These alterations were largely replicable through validation analysis. Our findings indicated the imbalance of connectivity in patients with post-stroke motor dysfunctions.

引用

页数：14