Monkeypox Resurgence: A Global Health Challenge Navigating Zoonotic Spillover, Genomic Evolution, and Strategic Response

In recent years, the global health landscape has been marked by the resurgence of infectious diseases that were once considered under control. Among these viruses, Monkeypox (Mpox), a zoonotic virus from the Orthopoxvirus genus, has emerged as a significant public health concern. Originally confined to central and western African regions, this zoonotic viral disease has spread to multiple countries, igniting discussions about its epidemiology, prevention, and control. Mpox has been declared a Public Health Emergency of International Concern by the World Health Organization [1], highlighting concerns over its global spread, zoonotic transmission, and evolving nature.