Anticonvulsant and gabapentinoids pharmacotherapy in the multiple sclerosis prodrome: A population-based matched cohort study

被引：0
作者：
Bergeron-Vitez, Himali [1 ,2 ]
Yusuf, Fardowsa L. A. [3 ,4 ]
Zhu, Feng [4 ]
Zhao, Yinshan [4 ]
Evans, Charity [5 ]
Fisk, John [6 ,7 ]
Marrie, Ruth Ann [8 ,9 ]
Kramer, John L. K. [1 ,2 ,4 ]
Tremlett, Helen [4 ]
机构：
[1] Univ British Columbia, Int Collaborat Repair Discoveries ICORD, Vancouver, BC, Canada
[2] Univ British Columbia, Fac Med, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC, Canada
[3] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada
[4] Univ British Columbia, Fac Med Neurol, Djavad Mowafaghian Ctr Brain Hlth, Vancouver, BC, Canada
[5] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK, Canada
[6] Dalhousie Univ, Nova Scotia Hlth, Halifax, NS, Canada
[7] Dalhousie Univ, Dept Psychiat Psychol & Neurosci & Med, Halifax, NS, Canada
[8] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Hlth Sci Ctr,Dept Internal Med, Winnipeg, MB, Canada
[9] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Hlth Sci Ctr,Dept Community Hlth Sci, Winnipeg, MB, Canada
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2025年 / 93卷
关键词：
Multiple sclerosis; Prodrome; pain; Neuropathic; Health administrative data;
D O I：
10.1016/j.msard.2024.106167
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Before disease onset, multiple sclerosis (MS) persons fill more prescriptions than controls, including for pain. However, knowledge regarding neuropathic pain-related medications is lacking Objective: Compare odds of anticonvulsant/gabapentinoid prescriptions for 4,862 MS-cases versus 22,669 controls, pre-MS onset (defined as first demyelinating disease-related event). Methods: Matched-cohort study using administrative data (1996-2013), comparing the odds of anticonvulsant/ gabapentinoid prescriptions pre-MS onset using multivariable logistic regression. Results: Versus controls, MS-cases were more likely to fill prescriptions for anticonvulsants (aOR[adjusted odds ratios] = 3.1,95 % confidence interval[CI]:2.8,3.4), gabapentinoids (aOR = 4.1,95 %CI:3.6,4.6), and gabapentinoids without anticonvulsants (aOR = 3.9,95 %CI:3.4,4.5). Conclusion: MS-cases filled anticonvulsant and gabapentinoid prescriptions more than matched controls pre-MS onset.
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页数：4
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