FGF-7 treatment accelerates wound healing in concentration-dependent manner by regulating TGF-β1 and VEGF expression

被引：0
作者：
Kim, Young-Sik [1 ]
Jeong, Gun-Jae [2 ]
Lee, Jung Soo [1 ]
Jang, Ju Woong [1 ]
Kim, Sae Hyun [2 ]
Chun, Heung Jae [2 ,3 ]
Yang, Dae Hyeok [2 ]
机构：
[1] Cellumed Co Ltd, Inst Biomat & Med Engn, Seoul 08589, South Korea
[2] Catholic Univ Korea, Inst Cell & Tissue Engn, Coll Med, Seoul 06591, South Korea
[3] Catholic Univ Korea, Coll Med, Dept Med Life Sci, Seoul 06591, South Korea
来源：
MACROMOLECULAR RESEARCH | 2025年 / 33卷 / 05期
关键词：
FGF-7; TGF-beta; 1; Hydroxyproline; Wound healing; ENDOTHELIAL GROWTH-FACTOR; MIGRATION; MATRIX; RATS;
D O I：
10.1007/s13233-024-00358-3
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this study, we report the effects of fibroblast growth factor-7 (FGF-7) concentration on wound healing, which has been less extensively studied compared to other growth factors. Assessment of the concentration-dependent effects of FGF-7 in an in vitro cell scratch assay showed that FGF-7 promoted human HaCaT keratinocyte migration into the wound area. In an in vivo animal test, local treatment with FGF-7 (up to 100 mu g) resulted in no toxicity. In addition, we found that when 100 mu g of FGF-7 was administered, transforming growth factor-beta 1 (TGF-beta 1), vascular endothelial growth factor (VEGF), and hydroxyproline, which are all related to wound healing, were significantly upregulated, followed by accelerated wound healing. All our results demonstrated that the FGF-7 concentration affects wound healing, and a dose of 100 mu g of FGF-7 exhibited the most pronounced wound healing effect.Graphical abstractIncreased wound recovery effect according to increased FGF-7 concentration in an in vivo wound model
引用
收藏
页码：655 / 665
页数：11
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