Concomitant diagnosis of Trypanosoma cruzi and HIV in a patient with neurologic manifestations: A case report

被引:0
作者
Solano, Emmanuel Molina [1 ]
Diaz, Mauricio Mora [2 ]
Madriz, Stephanie Montoya [1 ]
Calvo, Mauricio Lizano [1 ]
Moreira, Lissette Retana [3 ,4 ]
机构
[1] Caja Costarricense Seguro Social CCSS, Hosp Dr Maximiliano Peralta, Lab Clin, Cartago, Costa Rica
[2] Caja Costarricense Seguro Social CCSS, Hosp Dr Maximiliano Peralta, Dept Infectol, Cartago, Costa Rica
[3] Univ Costa Rica, Fac Microbiol, Dept Parasitol, San Jose, Costa Rica
[4] Univ Costa Rica, Ctr Invest Enfermedades Trop CIET, San Jose, Costa Rica
关键词
Trypanosoma cruzi; HIV; neurologic; nifurtimox; CHAGAS-DISEASE;
D O I
10.1016/j.bjid.2024.104478
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
American trypanosomiasis or Chagas disease is a vector-borne infection caused by the protozoan parasite Trypanosoma cruzi, characterized by acute and chronic phases; reactivations due to immunosuppression can occur. In this case report, we confirm the presence of trypomastigotes of T. cruzi in a patient with neurologic manifestations. For this purpose, a battery of techniques, including direct examination of cerebrospinal fluid, Giemsa stains, sample cultures, serology and molecular techniques were employed. The patient was treated with nifurtimox for 6 months and started antiretroviral therapy as the concomitant diagnosis of HIV was also performed, showing no sequelae nor adverse effects. A follow-up of the patient<acute accent>s health status was performed for 42 months.
引用
收藏
页数:4
相关论文
共 19 条
[1]  
Apt W, 2017, Treatment of Chagas disease. American trypanosomiasis Chagas disease: one hundred years of research
[2]   Pathology and Pathogenesis of Chagas Heart Disease [J].
Bonney, Kevin M. ;
Luthringer, Daniel J. ;
Kim, Stacey A. ;
Garg, Nisha J. ;
Engman, David M. .
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 14, 2019, 14 :421-447
[3]   Chagas Disease in People with HIV: A Narrative Review [J].
Clark, Eva H. ;
Bern, Caryn .
TROPICAL MEDICINE AND INFECTIOUS DISEASE, 2021, 6 (04)
[4]   Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992-2007 [J].
Cordova, Ezequiel ;
Boschi, Analia ;
Ambrosioni, Juan ;
Cudos, Carolina ;
Corti, Marcelo .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2008, 12 (06) :587-592
[5]   Co-infection Trypanosoma cruzi/HIV: systematic review (1980-2010) [J].
de Almeida, Eros Antonio ;
Ramos Junior, Alberto Novaes ;
Correia, Dalmo ;
Shikanai-Yasuda, Maria Aparecida .
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 2011, 44 (06) :762-770
[6]   Case Report: Meningoencephalitis Caused by Reactivation of Chagas Disease in Patient without Known Immunosuppression [J].
Fernandes, Herbert J. ;
Barbosa, Luanda O. F. ;
Machado, Tamara S. ;
Campos, Joao Paulo R. ;
Moura, Alexandre S. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2017, 96 (02) :292-294
[7]   Chagas Disease: From Discovery to a Worldwide Health Problem [J].
Freitas Lidani, Karita Claudia ;
Andrade, Fabiana Antunes ;
Bavia, Lorena ;
Damasceno, Flavia Silva ;
Beltrame, Marcia Holsbach ;
Messias-Reason, Iara J. ;
Sandri, Thaisa Lucas .
FRONTIERS IN PUBLIC HEALTH, 2019, 7
[8]   HIV and Chagas Disease Coinfection, a Tractable Disease? [J].
Guidetto, Betiana ;
Tatta, Melisa ;
Latini, Veronica ;
Gonzales, Milene ;
Riarte, Adelina ;
Tavella, Silvina ;
Warley, Eduardo ;
Altclas, Javier .
OPEN FORUM INFECTIOUS DISEASES, 2019, 6 (07)
[9]   Coinfection with HIV and tropical infectious diseases. II. Helminthic, fungal, bacterial, and viral pathogens [J].
Karp, Christopher L. ;
Auwaerter, Paul G. .
CLINICAL INFECTIOUS DISEASES, 2007, 45 (09) :1214-1220
[10]   Cerebral Trypanosomiasis in an Immunocompromised Patient: Case Report and Review of the Literature [J].
Kaushal, Mayank ;
Shabani, Saman ;
Cochran, Elizabeth J. ;
Samra, Hasan ;
Zwagerman, Nathan T. .
WORLD NEUROSURGERY, 2019, 129 :225-231