Evidence to Support the Collaboration of SP1, MYC, and HIF1A and Their Association with microRNAs

被引:0
作者
Chun, Jong Ho [1 ]
Kimura, Kotohiko [1 ]
Rajput, Monika [1 ,2 ]
Hsu, Ming-Hua [3 ]
Liang, Yu-Chuan [4 ]
Shanbhag, Akanksha Ramadas [1 ,5 ]
Chiang, Pei-Ju [6 ]
Jackson, Tiffany L. B. [1 ]
Huang, Ru Chih C. [1 ,7 ]
机构
[1] Johns Hopkins Univ, Dept Biol, 3400 N Charles St Levi Hall 250, Baltimore, MD 21218 USA
[2] Banaras Hindu Univ, Inst Med Sci, Dept Surg Oncol, Varanasi 221005, Uttar Pradesh, India
[3] Natl Changhua Univ Educ, Dept Chem, Changhua 500, Taiwan
[4] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 11529, Taiwan
[5] Johns Hopkins Univ, Adv Acad Programs, Baltimore, MD 21218 USA
[6] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA
[7] Acad Sinica, Taipei 115, Taiwan
基金
美国国家卫生研究院;
关键词
M4N; SP1; MYC; HIF1A; anticancer; stem cell; METHYLATED NORDIHYDROGUAIARETIC ACIDS; EPITHELIAL-MESENCHYMAL TRANSITION; C-MYC; ANTIVIRAL ACTIVITIES; CANCER; EXPRESSION; GROWTH; CELLS; TRANSCRIPTION; INHIBITION;
D O I
10.3390/cimb46110741
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This study provides evidence to support the concept proposed by Kimura et al. in 2023 that the inhibitors of SP1, MYC, and HIF1A should induce strong anticancer activity by reducing the expression of stem cell-related proteins. In LN229 and U87MG glioblastoma cells, either tetra-methyl-O-nordihydroguaiaretic acid (M4N) or tetra-acetyl-O-nordihydroguaiaretic acid (A4N) suppressed SP1 and only a few stem cell-related proteins and induced only a small amount of cell death; in contrast, the combination treatment of M4N with A(4)N greatly suppressed the expression of SP1, MYC, and HIF1A, as well as all of the stem cell-related proteins examined, and greatly induced cell death. The bioinformatic analysis showed that the proteins associated with SP1, MYC, and HIF1A were specifically involved in the regulation of transcription and that various microRNAs (miRNAs) that had been shown to induce either anti- or procancer activity were associated with SP1, MYC, and HIF1A, which suggested that the inhibition of SP1, MYC, and HIF1A could modulate the transcription of both coding and noncoding RNAs and affect cancers. These data overall supported our concept.
引用
收藏
页码:12481 / 12496
页数:16
相关论文
共 65 条
  • [11] Emerging Role of Glioma Stem Cells in Mechanisms of Therapy Resistance
    Eckerdt, Frank
    Platanias, Leonidas C.
    [J]. CANCERS, 2023, 15 (13)
  • [12] Role of microRNA-33a in malignant cells
    Gao, Chang
    Wei, Jiaen
    Tang, Tingting
    Huang, Zunnan
    [J]. ONCOLOGY LETTERS, 2020, 20 (03) : 2537 - 2556
  • [13] CHARACTERIZATION OF ANTI-HIV LIGNANS FROM LARREA-TRIDENTATA
    GNABRE, J
    HUANG, RCC
    BATES, RB
    BURNS, JJ
    CALDERA, S
    MALCOMSON, ME
    MCCLURE, KJ
    [J]. TETRAHEDRON, 1995, 51 (45) : 12203 - 12210
  • [14] Isolation of anti-HIV-1 lignans from Larrea tridentata by counter-current chromatography
    Gnabre, JN
    Ito, Y
    Ma, Y
    Huang, RC
    [J]. JOURNAL OF CHROMATOGRAPHY A, 1996, 719 (02) : 353 - 364
  • [15] INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TRANSCRIPTION AND REPLICATION BY DNA SEQUENCE-SELECTIVE PLANT LIGNANS
    GNABRE, JN
    BRADY, JN
    CLANTON, DJ
    ITO, Y
    DITTMER, J
    BATES, RB
    HUANG, RCC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) : 11239 - 11243
  • [16] Phase I study of terameprocol in patients with recurrent high-grade glioma
    Grossman, Stuart A.
    Ye, Xiaobu
    Peereboom, David
    Rosenfeld, Myrna R.
    Mikkelsen, Tom
    Supko, Jeffrey G.
    Desideri, Serena
    [J]. NEURO-ONCOLOGY, 2012, 14 (04) : 511 - 517
  • [17] The association between let-7, RAS and HIF-1α in Ewing Sarcoma tumor growth
    Hameiri-Grossman, Michal
    Porat-Klein, Adi
    Yaniv, Isaac
    Ash, Shifra
    Cohen, Ian J.
    Kodman, Yona
    Haklai, Ronit
    Elad-Sfadia, Galit
    Kloog, Yoel
    Chepurko, Elena
    Feinmesser, Meora
    Issakov, Josephine
    Sher, Osnat
    Luria, Drorit
    Kollender, Yehuda
    Weizman, Avraham
    Avigad, Smadar
    [J]. ONCOTARGET, 2015, 6 (32) : 33834 - 33848
  • [18] Heller JD, 2001, CANCER RES, V61, P5499
  • [19] Recent advances in the functional explorations of nuclear microRNAs
    Hu, Xiaozhu
    Yin, Guoquan
    Zhang, Yuan
    Zhu, Liangyu
    Huang, Haoyu
    Lv, Kun
    [J]. FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [20] Huang R.C., 2013, Patent No. [U.S.9456995B2, 9456995]