Current Practices and Considerations in Lung Biopsy for Suspected Granulomatous-Lymphocytic Interstitial Lung Disease: A Clinician Survey

被引：1

作者：

Bintalib, Heba M. ^{[1
,2
,3
]}

Davidsen, Jesper Romhild ^{[4
,5
]}

van de Ven, Annick A. J. M. ^{[6
,7
]}

Goddard, Sarah ^{[8
]}

Burns, Siobhan O. ^{[9
,10
]}

Warnatz, Klaus ^{[11
,12
]}

Hurst, John R. ^{[1
]}

机构：

[1] Univ Coll London Hosp, London, England

[2] King Saud Bin Abdulaziz Univ Hlth Sci, Dept Pharmacol, Jeddah, Saudi Arabia

[3] King Abdullah Int Med Res Ctr, Jeddah, Saudi Arabia

[4] Odense Univ Hosp, South Danish Ctr Interstitial Lung Dis SCILS, Dept Resp Med, Odense, Denmark

[5] Univ Southern Denmark, Dept Clin Res, Odense Resp Res Unit ODIN, Odense, Denmark

[6] Univ Med Ctr Groningen, Dept Internal Med & Allergol, Groningen, Netherlands

[7] Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, Groningen, Netherlands

[8] Univ Hosp North Midlands, Royal Stoke Hosp, Dept Cardiothorac Surg, Stoke On Trent, England

[9] UCL, Inst Immun & Transplantat, London, England

[10] Royal Free London NHS Fdn Trust, Dept Immunol, London, England

[11] Univ Freiburg, Fac Med, Med Ctr, Dept Rheumatol & Clin Immunol, Freiburg, Germany

[12] Univ Freiburg, Fac Med, Ctr Chron Immunodeficiency CCI, Med Ctr, Freiburg, Germany

来源：

RESPIRATION | 2024年 / 103卷 / 11期

关键词：

Common variable immunodeficiency; Granulomatous-lymphocytic interstitial lung disease; Diagnosis; Lung biopsy; DIAGNOSIS; PREDICTORS;

D O I：

10.1159/000540101

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction: This study explores clinicians' diagnostic practices and perceptions in the context of granulomatouslymphocytic interstitial lung disease (GLILD), a pulmonary manifestation of common variable immunodeficiency disorder. The aim was to gain valuable insights into key aspects, such as the utilization of radiological features for diagnostic purposes, indications for lung biopsy, preferred biopsy techniques, and the relative importance of different histo pathological findings in confirming GLILD. Method: A survey targeting expert clinicians was conducted, focusing on their experiences, practices, and attitudes towards lung biopsy in suspected GLILD cases. Results: The survey revealed that the majority of respondents accepted high-resolution computed tomography as a sufficient alternative to biopsy for making a probable GLILD diagnosis in most patients. There was a consensus among most respondents that the presence of extrapulmonary granulomatous disease is adequate for making a diagnosis of GLILD where the chest imaging and clinical picture are consistent. When a biopsy was recommended, there was notable variation in the preferred initial biopsy technique, with 35% favouring transbronchial biopsy. Conclusion: Our findings underscore the complexity of diagnosing GLILD, indicating varied clinician opinions on the necessity and efficacy of lung biopsies. They highlight the need for further research and the development of consistent diagnostic criteria and management protocols, ultimately aiming to enhance the accuracy and safety of GLILD diagnosis and treatment strategies. (c) 2024 The Author(s). Published by S. Karger AG, Basel

引用

页码：692 / 700

页数：9