Comparative Immunohistochemical Analysis of Craniopharyngioma and Ameloblastoma: Insights into Odontogenic Differentiation

被引：0
作者：
Salih, Ban A. [1 ]
Abdullah, Bashar H. [1 ]
机构：
[1] Univ Baghdad, Coll Dent, Baghdad 10071, Iraq
来源：
DIAGNOSTICS | 2024年 / 14卷 / 20期
关键词：
craniopharyngioma; ameloblastoma; odontogenic differentiation; immunohistochemistry; CYTOKERATIN; 19; PROTEIN ODAM; EXPRESSION; AMELOGENIN; TUMORS;
D O I：
10.3390/diagnostics14202315
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and objectives: Histopathological similarities between craniopharyngioma (CP) and ameloblastoma (AB) have long been recognized, particularly the shared features of palisading columnar epithelium and stellate reticulum-like areas. This study aimed to investigate potential odontogenic differentiation in CP akin to AB using immunohistochemical odontogenic markers. Methods: We analyzed AMELX, ODAM, and CK19 expression in 44 cases (20 CP and 24 AB). Results: While AMELX and ODAM showed diffuse strong positive expression in both tumors with no significant statistical differences, CK19 expression was notably higher in CP. Conclusion: The markers AMELX and ODAM associated with odontogenic differentiation exhibited similar profiles in both tumors due to shared similar embryological origins. Notably, CK19, a biomarker of odontogenic epithelium, showed even higher expression, suggesting distinct pathways. These findings offer insights into tumor biology and may aid in diagnostic and therapeutic approaches.
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