Heart rate variability wrist-wearable biomarkers identify adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure

被引：1

作者：

Guichard, Lauriane ^{[1
]}

An, Xinming ^{[2
]}

Neylan, Thomas C. ^{[3
,4
]}

Clifford, Gari D. ^{[5
,6
,7
]}

Li, Qiao ^{[5
]}

Ji, Yinyao ^{[8
]}

Macchio, Lindsay ^{[9
]}

Baker, Justin ^{[10
,11
,12
]}

Beaudoin, Francesca L. ^{[13
,14
]}

Jovanovic, Tanja ^{[15
]}

Linnstaedt, Sarah D. ^{[2
]}

Germine, Laura T. ^{[10
,12
,16
]}

Bollen, Kenneth A. ^{[17
,18
]}

Rauch, Scott L. ^{[10
,12
,19
]}

Haran, John P. ^{[20
]}

Storrow, Alan B. ^{[21
]}

Lewandowski, Christopher ^{[22
]}

Musey, Jr Paul, I ^{[23
]}

Hendry, Phyllis L. ^{[24
]}

Sheikh, Sophia ^{[24
]}

Jones, Christopher W. ^{[25
]}

Punches, Brittany E. ^{[26
,27
]}

Swor, Robert A. ^{[28
]}

Gentilez, Nina T. ^{[29
]}

Pascual, Jose L. ^{[30
,31
]}

Seamon, Mark J. ^{[31
,32
]}

Datner, Elizabeth M. ^{[33
,34
]}

Pearson, Claire ^{[35
]}

Peak, David A. ^{[36
]}

Merchant, Roland C. ^{[37
]}

Domeier, Robert M. ^{[38
]}

Rathlev, Niels K. ^{[39
]}

O'Neil, Brian J. ^{[40
]}

Sergot, Paulina ^{[41
]}

Sanchez, Leon D. ^{[37
,42
]}

Bruce, Steven E. ^{[43
]}

Sheridan, John F. ^{[44
,45
]}

Harte, Steven E. ^{[46
,47
]}

Ressler, Kerry J. ^{[12
,48
]}

Koenen, Karestan C. ^{[49
]}

Kessler, Ronald C. ^{[50
]}

McLean, Samuel A. ^{[8
,51
]}

机构：

[1] Univ N Carolina, Dept Anesthesiol, N2198 UNC Hosp,CB 7010, Chapel Hill, NC 27559 USA

[2] Univ N Carolina, Dept Anesthesiol, Inst Trauma Recovery, Chapel Hill, NC 27559 USA

[3] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[5] Emory Univ, Sch Med, Dept Biomed Informat, Atlanta, GA 30332 USA

[6] Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA

[7] Emory Univ, Atlanta, GA 30332 USA

[8] Univ N Carolina, Inst Trauma Recovery, Chapel Hill, NC 27559 USA

[9] UNC, Sch Med, Inst Trauma Recovery, Chapel Hill, NC 27559 USA

[10] McLean Hosp, Inst Technol Psychiat, Belmont, MA 02478 USA

[11] McLean Hosp, Schizophrenia & Bipolar Disorder Res Program, Belmont, MA 02478 USA

[12] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[13] Brown Univ, Dept Epidemiol, Providence, RI 02930 USA

[14] Brown Univ, Dept Emergency Med, Providence, RI 02930 USA

[15] Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI 48202 USA

[16] Many Brains Project, Belmont, MA 02478 USA

[17] Univ N Carolina, Dept Psychol & Neurosci, Chapel Hill, NC 27599 USA

[18] Univ N Carolina, Dept Sociol, Chapel Hill, NC 27559 USA

[19] McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA

[20] Univ Massachusetts, Chan Med Sch, Dept Emergency Med, Worcester, MA 01655 USA

[21] Vanderbilt Univ, Med Ctr, Dept Emergency Med, Nashville, TN 37232 USA

[22] Henry Ford Hlth Syst, Dept Emergency Med, Detroit, MI 48202 USA

[23] Indiana Univ Sch Med, Dept Emergency Med, Indianapolis, IN 46202 USA

[24] Univ Florida, Coll Med Jacksonville, Dept Emergency Med, Jacksonville, FL 32209 USA

[25] Rowan Univ, Dept Emergency Med, Cooper Med Sch, Camden, NJ 08103 USA

[26] Ohio State Univ, Coll Med, Dept Emergency Med, Columbus, OH 43210 USA

[27] Ohio State Univ, Coll Nursing, Columbus, OH 43210 USA

[28] Oakland Univ, William Beaumont Sch Med, Dept Emergency Med, Rochester, MI 48309 USA

[29] Temple Univ, Lewis Katz Sch Med, Dept Emergency Med, Philadelphia, PA 19121 USA

[30] Univ Penn, Dept Surg, Dept Neurosurg, Philadelphia, PA 19104 USA

[31] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[32] Univ Penn, Dept Surg, Div Traumatol Surg Crit Care & Emergency Surg, Philadelphia, PA 19104 USA

[33] Jefferson Hlth, Jefferson Einstein Hosp, Dept Emergency Med, Philadelphia, PA 19141 USA

[34] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Emergency Med, Philadelphia, PA 19107 USA

[35] Wayne State Univ, Ascension St John Hosp, Dept Emergency Med, Detroit, MI 48202 USA

[36] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA

[37] Brigham & Womens Hosp, Dept Emergency Med, Boston, MA 02115 USA

[38] Trinity Hlth Ann Arbor, Dept Emergency Med, Ypsilanti, MI 48197 USA

[39] Univ Massachusetts, Med Sch Baystate, Dept Emergency Med, Springfield, MA 01107 USA

[40] Wayne State Univ, Detroit Receiving Hosp, Dept Emergency Med, Detroit, MI 48202 USA

[41] UTHealth, McGovern Med Sch, Dept Emergency Med, Houston, TX 77030 USA

[42] Harvard Med Sch, Dept Emergency Med, Boston, MA 02115 USA

[43] Univ Missouri St Louis, Dept Psychol Sci, St Louis, MO 63121 USA

[44] Ohio State Univ, Coll Dent, Div Biosci, Columbus, OH 43210 USA

[45] OSU Wexner Med Ctr, Inst Behav Med Res, Columbus, OH 43211 USA

[46] Univ Michigan, Med Sch, Dept Anesthesiol, Ann Arbor, MI 48109 USA

[47] Univ Michigan, Med Sch, Dept Internal Med Rheumatol, Ann Arbor, MI 48109 USA

[48] McLean Hosp, Div Depress & Anxiety, Belmont, MA 02478 USA

[49] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[50] Harvard Med Sch, Dept Hlth Care Policy, Boston, MA 02115 USA

来源：

PSYCHIATRY RESEARCH | 2024年 / 342卷

关键词：

Posttraumatic stress disorder; Pain; Stress-response system; Wrist-wearable device; MOTOR-VEHICLE COLLISION; CHRONIC PAIN; MAJOR DEPRESSION; BRAIN-INJURY; DISORDER; SYMPTOMS; ASSOCIATION; SLEEP; PTSD; PATHOPHYSIOLOGY;

D O I：

10.1016/j.psychres.2024.116260

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Adverse posttraumatic neuropsychiatric sequelae (APNS) are common after traumatic events. We examined whether wrist-wearable devices could provide heart rate variability (HRV) biomarkers for recovery after traumatic stress exposure in a large socioeconomically disadvantaged cohort. Participants were enrolled in the emergency department within 72 hours after a traumatic event as part of the AURORA (Advancing Understanding of RecOvery afteR traumA) multicenter prospective observational cohort study and followed over 6 months. HRV biomarkers were derived and validated for associations with specific APNS symptoms at a point in time and changes in symptom severity over time. Sixty-four HRV characteristics were derived and validated as cross-sectional biomarkers of APNS symptoms, including pain (26), re-experiencing (8), somatic (7), avoidance (7), concentration difficulty (6), hyperarousal (5), nightmares (1), anxiety (1), and sleep disturbance (3). Changes in 22 HRV characteristics were derived and validated as biomarkers identifying changes in APNS symptoms, including reexperiencing (11), somatic (3), avoidance (2), concentration difficulty (1), hyperarousal (1), and sleep disturbance (4). Changes in HRV variables over time predicted symptom improvement (PPV 0.68-0.87) and symptom worsening (NPV 0.71-0.90). HRV biomarkers collected from wrist-wearable devices may have utility as screening tools for APNS symptoms that occur after traumatic stress exposure in high-risk populations.

引用

页数：12

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