m6A modification: a new avenue for anti-cancer therapy

被引：4

作者：

Bai, Yongtai ^{[1
]}

Li, Kai ^{[1
,2
,3
]}

Peng, Jinying ^{[1
]}

Yi, Chengqi ^{[1
,3
,4
,5
]}

机构：

[1] Peking Univ, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China

[2] Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China

[3] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

[4] Peking Univ, Coll Chem & Mol Engn, Dept Chem Biol, Beijing 100871, Peoples R China

[5] Peking Univ, Coll Chem & Mol Engn, Synthet & Funct Biomol Ctr, Beijing 100871, Peoples R China

来源：

LIFE MEDICINE | 2023年 / 2卷 / 01期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

m(6)A; RNA modification; METTL3; FTO; cancer therapy; METHYLTRANSFERASE METTL3 PROMOTES; MESSENGER-RNA STABILITY; BREAST-CANCER; NUCLEAR-RNA; BINDING-PROTEIN; TRANSLATION; N-6-METHYLADENOSINE; METHYLATION; N6-METHYLADENOSINE; PROGRESSION;

D O I：

10.1093/lifemedi/lnad008

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To date, over 170 different kinds of chemical modifications on RNAs have been identified, some of which are involved in multiple aspects of RNA fate, ranging from RNA processing, nuclear export, translation, and RNA decay. m(6)A, also known as N-6-methyladenosine, is a prominent internal RNA modification that is catalyzed primarily by the METTL3-METTL14-WTAP methyltransferase complex in higher eukaryotic mRNA and long noncoding RNA (lncRNA). In recent years, abnormal m(6)A modification has been linked to the occurrence, development, progression, and prognosis of the majority of cancers. In this review, we provide an update on the most recent m(6)A modification discoveries as well as the critical roles of m(6)A modification in cancer development and progression. We summarize the mechanisms of m(6)A involvement in cancer and list potential cancer therapy inhibitors that target m(6)A regulators such as "writer" METTL3 and "eraser" FTO.

引用

页数：10

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