Research Progress on Cyclic-Peptide Functionalized Nanoparticles for Tumor-Penetrating Delivery

被引：2

作者：

Wang, Chenkai ^{[1
,2
]}

Shen, Zefan ^{[1
,2
]}

Chen, Yiyang ^{[1
,2
]}

Wang, Yifan ^{[2
]}

Zhou, Xuanyi ^{[2
]}

Chen, Xinyi ^{[1
]}

Li, Yuhang ^{[2
]}

Zhang, Pu ^{[2
]}

Zhang, Qi ^{[2
]}

机构：

[1] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China

[2] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Urol & Nephrol Ctr,Dept Urol, Hangzhou 310014, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2024年 / 19卷

基金：

中国国家自然科学基金;

关键词：

cyclic peptide; tumor penetration; drug delivery; nanomaterial functionalization; ARGININE-RICH PEPTIDES; BICYCLIC PEPTIDES; TUNNELING NANOTUBES; CELL; PERMEABILITY; STRATEGIES; CHEMOTHERAPY; CONJUGATION; STABILITY; RECEPTOR;

D O I：

10.2147/IJN.S487303

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A key challenge in cancer treatment is the effective delivery of drugs into deep regions of tumor tissues, which are impermeable due to abnormal vascular network, increased interstitial fluid pressure (IFP), abundant extra cellular matrix (ECM), and heterogeneity of tumor cells. Cyclic peptides have been used for the surface engineering of nanoparticles to enhance the tumor- penetrating efficacy of drugs. Compared with other surface ligands, cyclic peptides are more easily produced by automated chemical synthesis, and they are featured by their higher binding affinity with their targets, tumor selectivity, stability against degradation, and low toxicity. In this review, different types of cyclic peptides, their physicochemical properties and their in vivo pharmacokinetics are introduced. Next, the progress of cyclic peptide-functionalized drug delivery nanodevices is updated, and the mechanism underlying the tumor-penetrating properties of cyclic peptide-functionalized drug delivery nanodevices is discussed.

引用

页码：12633 / 12652

页数：20

共 105 条

[1] De Novo Design of a Tumor-Penetrating Peptide [J].

Alberici, Luca ;

Roth, Lise ;

Sugahara, Kazuki N. ;

Agemy, Lilach ;

Kotamraju, Venkata R. ;

Teesalu, Tambet ;

Bordignon, Claudio ;

Traversari, Catia ;

Rizzardi, Gian-Paolo ;

Ruoslahti, Erkki .

CANCER RESEARCH, 2013, 73 (02) :804-812

[2] Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions [J].

Ariazi, Jennifer ;

Benowitz, Andrew ;

De Biasi, Vern ;

Den Boer, Monique L. ;

Cherqui, Stephanie ;

Cui, Haifeng ;

Douillet, Nathalie ;

Eugenin, Eliseo A. ;

Favre, David ;

Goodman, Spencer ;

Gousset, Karine ;

Hanein, Dorit ;

Israel, David I. ;

Kimura, Shunsuke ;

Kirkpatrick, Robert B. ;

Kuhn, Nastaran ;

Jeong, Claire ;

Lou, Emil ;

Mailliard, Robbie ;

Maio, Stephen ;

Okafo, George ;

Osswald, Matthias ;

Pasquier, Jennifer ;

Polak, Roel ;

Pradel, Gabriele ;

de Rooij, Bob ;

Schaeffer, Peter ;

Skeberdis, Vytenis A. ;

Smith, Ian F. ;

Tanveer, Ahmad ;

Volkmann, Niels ;

Wu, Zhenhua ;

Zurzolo, Chiara .

FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 10

[3] Macrocyclization strategies for cyclic peptides and peptidomimetics [J].

Bechtler, Clement ;

Lamers, Christina .

RSC MEDICINAL CHEMISTRY, 2021, 12 (08) :1325-1351

[4] Peptide receptor radionuclide therapy (PRRT) for GEP-NETs [J].

Bergsma, Hendrik ;

van Vliet, Esther I. ;

Teunissen, Jaap J. M. ;

Kam, Boen L. R. ;

de Herder, Wouter W. ;

Peeters, Robin P. ;

Krenning, Eric P. ;

Kwekkeboom, Dik J. .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2012, 26 (06) :867-881

[5] Accurate de novo design of membrane-traversing macrocycles [J].

Bhardwaj, Gaurav ;

O'Connor, Jacob ;

Rettie, Stephen ;

Huang, Yen-Hua ;

Ramelot, Theresa A. ;

Mulligan, Vikram Khipple ;

Alpkilic, Gizem Gokce ;

Palmer, Jonathan ;

Bera, Asim K. ;

Bick, Matthew J. ;

Di Piazza, Maddalena ;

Li, Xinting ;

Hosseinzadeh, Parisa ;

Craven, Timothy W. ;

Tejero, Roberto ;

Lauko, Anna ;

Choi, Ryan ;

Glynn, Calina ;

Dong, Linlin ;

Griffin, Robert ;

Voorhis, Wesley C. van ;

Rodriguez, Jose ;

Stewart, Lance ;

Montelione, Gaetano T. ;

Craik, David ;

Baker, David .

CELL, 2022, 185 (19) :3520-+

[6] Drug Conjugation to Cyclic Peptide-Polymer Self-Assembling Nanotubes [J].

Blunden, Bianca M. ;

Chapman, Robert ;

Danial, Maarten ;

Lu, Hongxu ;

Jolliffe, Katrina A. ;

Perrier, Sebastien ;

Stenzel, Martina H. .

CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (40) :12745-12749

[7] Electrostatic Conjugation of Nanoparticle Surfaces with Functional Peptide Motifs [J].

Boehnke, Natalie ;

Dolph, Kate J. ;

Juarez, Valeria M. ;

Lanoha, Julia M. ;

Hammond, Paula T. .

BIOCONJUGATE CHEMISTRY, 2020, 31 (09) :2211-2219

[8] Solution stability of linear vs. cyclic RGD peptides [J].

Bogdanowich-Knipp, SJ ;

Chakrabarti, S ;

Williams, TD ;

Dillmall, RK ;

Siahaan, TJ .

JOURNAL OF PEPTIDE RESEARCH, 1999, 53 (05) :530-541

[9]

Borum Raina M, 2024, Npj imaging.., V2, P4, DOI 10.1038/s44303-024-00008-4

[10] The great escape: how cationic polyplexes overcome the endosomal barrier [J].

Bus, Tanja ;

Traeger, Anja ;

Schubert, Ulrich S. .

JOURNAL OF MATERIALS CHEMISTRY B, 2018, 6 (43) :6904-6918

← 1 2 3 4 5 6 7 8 9 10 →