The Mechanism of Acupuncture Regulating Autophagy: Progress and Prospect

被引：0
作者：
He, Jing [1 ]
He, Min [2 ]
Sun, Mengmeng [2 ]
Chen, Hongxiu [1 ]
Dou, Zhiqiang [1 ]
Nie, Ru [1 ]
Zhou, Jun [3 ]
Tang, Qingqing [1 ]
Che, Cong [1 ]
Liu, Jie [4 ]
Li, Tie [1 ]
机构：
[1] Changchun Univ Chinese Med, Dept Acupuncture & Tuina, Changchun 130117, Peoples R China
[2] Changchun Univ Chinese Med, Northeast Asia Res Inst Tradit Chinese Med, Changchun 130117, Peoples R China
[3] Tianjin Univ Tradit Chinese Med, Res Ctr Expt Acupuncture Sci, Tianjin 301617, Peoples R China
[4] Changchun Univ Chinese Med, Acad Affairs Off, Changchun 130117, Peoples R China
来源：
BIOMOLECULES | 2025年 / 15卷 / 02期
基金：
中国国家自然科学基金;
关键词：
autophagy; acupuncture therapy; acupoint; mechanism; signaling pathway; CEREBRAL ISCHEMIA/REPERFUSION INJURY; ENDOPLASMIC-RETICULUM STRESS; ISCHEMIA-REPERFUSION INJURY; HEAT-SHOCK PROTEINS; SIGNALING PATHWAY; MEDIATED AUTOPHAGY; OXIDATIVE STRESS; DNA-DAMAGE; ER STRESS; ELECTROACUPUNCTURE;
D O I：
10.3390/biom15020263
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Autophagy plays a crucial role in the physiopathological mechanisms of diseases by regulating cellular functions and maintaining cellular homeostasis, which has garnered extensive attention from researchers worldwide. The holistic regulation and bidirectional regulation effects of acupuncture can modulate cellular autophagy, promoting or restoring the homeostasis of the body's internal environment to achieve therapeutic outcomes. This paper systematically reviews the research progress on the use of acupuncture for treating various diseases via the autophagy pathway, summarizes signal pathways related to acupuncture regulating autophagy, and analyzes the deficiencies present in the existing research. The review results indicate that the mechanism of action of acupuncture on autophagy dysfunction is reflected in the changes in LC3, Beclin1, p53, and autophagy-associated (ATG) protein expression, and regulates signaling pathways and key proteins or genes. The regulatory effect of acupuncture on autophagy capacity is bidirectional: it inhibits the abnormal activation of autophagy to prevent exacerbation of injury and reduce apoptosis, while also activating or enhancing autophagy to promote the elimination of inflammation and reduce oxidative stress. Further analysis suggests that the mechanisms of acupuncture regulating autophagy are insufficiently explored. Future research should prioritize the development of more appropriate animal models, analyzing the accuracy of relevant pathways and the specificity of indicators, exploring the synergistic effects among targets and signaling pathways, clarifying the regulatory mechanisms of acupuncture at various stages of autophagy, and evaluating the efficacy of acupuncture in autophagy modulating. This paper offers valuable insights into the regulation of autophagy by acupuncture.
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页数：26
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