Genetic characterization of rotavirus A strains circulating in children under 5 years of age with acute gastroenteritis in Tehran, Iran, in 2023-2024: dissemination of the emerging equine- like G3P[8]-I2-E2 DS-1-like strains

被引：0

作者：

Hosseini-Fakhr, Somayeh-Sadat ^{[1
]}

Jalilvand, Somayeh ^{[1
]}

Maleki, Ali ^{[2
,3
]}

Kachooei, Atefeh ^{[4
]}

Behnezhad, Farzane ^{[4
]}

Mir-Hosseinian, Mahtab ^{[5
]}

Taghvaei, Seiedehparnian ^{[6
]}

Marashi, Sayed Mahdi ^{[1
]}

Shoja, Zabihollah ^{[5
,7
]}

机构：

[1] Univ Tehran Med Sci, Sch Publ Hlth, Dept Virol, Tehran, Iran

[2] Pasteur Inst Iran, COVID 19 Natl Reference Lab CNRL, Tehran, Iran

[3] Pasteur Inst Iran, Dept Influenza & Resp Viruses, Tehran, Iran

[4] Iran Univ Med Sci, Sch Med, Dept Virol, Tehran, Iran

[5] Pasteur Inst Iran, Dept Virol, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Res Inst Childrens Hlth, Pediat Pathol Res Ctr, Tehran, Iran

[7] Pasteur Inst Iran, Res Ctr Emerging & Reemerging Infect Dis, Tehran, Iran

来源：

JOURNAL OF GENERAL VIROLOGY | 2025年 / 106卷 / 03期

关键词：

equine G3 strain; rotavirus; VP4 ANTIGENIC EPITOPES; MOLECULAR CHARACTERIZATION; G3; ROTAVIRUS; VACCINE; EFFICACY; JAPAN; SAFETY; IMMUNOGENICITY; CLASSIFICATION; HETEROGENEITY;

D O I：

10.1099/jgv.0.002088

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present study was conducted to monitor the genotype diversity of circulating species A rotavirus (RVA) in Iran. A total of 300 faecal specimens were collected from children under 5years of age hospitalized for acute gastroenteritis between October 2023 and October 2024. G3P[8] represented 72.91% (70/96) of all RVA- positive samples, further subdivided into equine- like G3P[8]-I2-E2 DS- 1- like and human G3P[8]-I1-E1 Wa-like. A retrospective genetic analysis of G3P[8] strains isolated from 2015 to 2017 was also performed and showed that G3P[8] strains belong to the G3P[8]-E1-I1 Wa-like genetic pattern, which is typically similar to human G3P[8] Wa-like strains in this study. The emergence of equine- like G3P[8] DS- 1- like strains in Iran may not be related to selection pressure from rotavirus vaccination, but rather to cross- border migration of rotavirus strains due to population movements.

引用

页数：12

共 70 条

[51] Kachooei A, Tava Koli A, Minaeian S, Hosseini M, Jalilvand S, Et al., Molecular characterization of rotavirus infections in children less than 5 years of age with acute gastroenteritis in Tehran, Iran, 2021-2022: emergence of uncommon G9P[4] and G9P[8] rotavirus strains, J Med Virol, 95, (2023)
[52] Degiuseppe JI, Parra GI, Stupka JA., Genetic diversity of G3 rotavirus strains circulating in argentina during 1998-2012 assessed by full genome analyses, PLoS One, 9, (2014)
[53] Gomez MM, Carvalho-Costa FA, Volotao E de M, Rose TL, da Silva MFM, Et al., A decade of G3P[8] and G9P[8] rotaviruses in Brazil: epidemiology and evolutionary analyses, Infect Genet Evol, 28, pp. 389-397, (2014)
[54] Phan TG, Khamrin P, Trinh DQ, Dey SK, Yagyu F, Et al., Genetic characterization of group A rotavirus strains circulating among children with acute gastroenteritis in Japan in 2004-2005, Infect Genet Evol, 7, pp. 247-253, (2007)
[55] Tamura K, Stecher G, Kumar S., MEGA11: molecular evolutionary genetics analysis version 11, Mol Biol Evol, 38, pp. 3022-3027, (2021)
[56] Aoki ST, Settembre EC, Trask SD, Greenberg HB, Harrison SC, Et al., Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab, Science, 324, pp. 1444-1447, (2009)
[57] Zeller M, Patton JT, Heylen E, De Coster S, Ciarlet M, Et al., Genetic analyses reveal differences in the VP7 and VP4 antigenic epitopes between human rotaviruses circulating in Belgium and rotaviruses in rotarix and rotateq, J Clin Microbiol, 50, pp. 966-976, (2012)
[58] Mwanga MJ, Verani JR, Omore R, Tate JE, Parashar UD, Et al., Multiple introductions and predominance of rotavirus group a genotype G3P[8] in kilifi, Coastal Kenya, 4 Years after nationwide vaccine introduction, Pathogens, 9, (2020)
[59] Mhango C, Mandolo JJ, Chinyama E, Wachepa R, Kanjerwa O, Et al., Rotavirus genotypes in hospitalized children with acute gastroenteritis before and after rotavirus vaccine introduction in Blantyre, Malawi, 1997-2019, J Infect Dis, 225, pp. 2127-2136, (2022)
[60] Joao ED, Munlela B, Chissaque A, Chilaule J, Langa J, Et al., Molecular epidemiology of rotavirus a strains pre- and post-vaccine (Rotarix<sup>®</sup>) introduction in mozambique, 2012-2019: emergence of genotypes G3P[4] and G3P[8], Pathogens, 9, (2020)

← 1 2 3 4 5 6 7 →