Genetic characterization of rotavirus A strains circulating in children under 5 years of age with acute gastroenteritis in Tehran, Iran, in 2023-2024: dissemination of the emerging equine- like G3P[8]-I2-E2 DS-1-like strains

被引：0

作者：

Hosseini-Fakhr, Somayeh-Sadat ^{[1
]}

Jalilvand, Somayeh ^{[1
]}

Maleki, Ali ^{[2
,3
]}

Kachooei, Atefeh ^{[4
]}

Behnezhad, Farzane ^{[4
]}

Mir-Hosseinian, Mahtab ^{[5
]}

Taghvaei, Seiedehparnian ^{[6
]}

Marashi, Sayed Mahdi ^{[1
]}

Shoja, Zabihollah ^{[5
,7
]}

机构：

[1] Univ Tehran Med Sci, Sch Publ Hlth, Dept Virol, Tehran, Iran

[2] Pasteur Inst Iran, COVID 19 Natl Reference Lab CNRL, Tehran, Iran

[3] Pasteur Inst Iran, Dept Influenza & Resp Viruses, Tehran, Iran

[4] Iran Univ Med Sci, Sch Med, Dept Virol, Tehran, Iran

[5] Pasteur Inst Iran, Dept Virol, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Res Inst Childrens Hlth, Pediat Pathol Res Ctr, Tehran, Iran

[7] Pasteur Inst Iran, Res Ctr Emerging & Reemerging Infect Dis, Tehran, Iran

来源：

JOURNAL OF GENERAL VIROLOGY | 2025年 / 106卷 / 03期

关键词：

equine G3 strain; rotavirus; VP4 ANTIGENIC EPITOPES; MOLECULAR CHARACTERIZATION; G3; ROTAVIRUS; VACCINE; EFFICACY; JAPAN; SAFETY; IMMUNOGENICITY; CLASSIFICATION; HETEROGENEITY;

D O I：

10.1099/jgv.0.002088

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present study was conducted to monitor the genotype diversity of circulating species A rotavirus (RVA) in Iran. A total of 300 faecal specimens were collected from children under 5years of age hospitalized for acute gastroenteritis between October 2023 and October 2024. G3P[8] represented 72.91% (70/96) of all RVA- positive samples, further subdivided into equine- like G3P[8]-I2-E2 DS- 1- like and human G3P[8]-I1-E1 Wa-like. A retrospective genetic analysis of G3P[8] strains isolated from 2015 to 2017 was also performed and showed that G3P[8] strains belong to the G3P[8]-E1-I1 Wa-like genetic pattern, which is typically similar to human G3P[8] Wa-like strains in this study. The emergence of equine- like G3P[8] DS- 1- like strains in Iran may not be related to selection pressure from rotavirus vaccination, but rather to cross- border migration of rotavirus strains due to population movements.

引用

页数：12

共 70 条

[31] Luchs A, da Costa AC, Cilli A, Komninakis SCV, Carmona R de CC, Et al., Spread of the emerging equine-like G3P[8] DS-1-like genetic backbone rotavirus strain in Brazil and identification of potential genetic variants, J Gen Virol, 100, pp. 7-25, (2019)
[32] Perkins C, Mijatovic-Rustempasic S, Ward ML, Cortese MM, Bowen MD., Genomic characterization of the first equine-like G3P[8] rotavirus strain detected in the United States, Genome Announc, 5, pp. 01341-01317, (2017)
[33] Utsumi T, Wahyuni RM, Doan YH, Dinana Z, Soegijanto S, Et al., Equine-like G3 rotavirus strains as predominant strains among children in Indonesia in 2015-2016, Infect Genet Evol, 61, pp. 224-228, (2018)
[34] Mhango C, Banda A, Chinyama E, Mandolo JJ, Kumwenda O, Et al., Comparative whole genome analysis reveals re-emergence of human Wa-like and DS-1-like G3 rotaviruses after Rotarix vaccine introduction in Malawi, Virus Evol, 9, (2023)
[35] Komoto S, Ide T, Negoro M, Tanaka T, Asada K, Et al., Characterization of unusual DS-1-like G3P[8] rotavirus strains in children with diarrhea in Japan, J Med Virol, 90, pp. 890-898, (2018)
[36] Roczo-Farkas S, Kirkwood CD, Cowley D, Barnes GL, Bishop RF, Et al., The impact of rotavirus vaccines on genotype diversity: a comprehensive analysis of 2 decades of Australian surveillance data, J Infect Dis, 218, pp. 546-554, (2018)
[37] Morozova OV, Sashina TA, Epifanova NV, Velikzhanina EI, Novikova NA., Phylodynamic characteristics of reassortant DS-1like G3P[8]-strains of rotavirus type a isolated in nizhny novgorod (Russia), Braz J Microbiol, 54, pp. 2867-2877, (2023)
[38] Malakalinga JJ, Misinzo G, Msalya GM, Shayo MJ, Kazwala RR., Genetic diversity and genomic analysis of G3P[6] and equine-like G3P[8] in children under-five from southern highlands and Eastern Tanzania, Acta Trop, 242, (2023)
[39] Martinez-Gutierrez M, Hernandez-Mira E, Rendon-Marin S, Ruiz-Saenz J., Wa-1 equine-like G3P[8] rotavirus from a child with diarrhea in Colombia, Viruses, 13, (2021)
[40] Manjate F, Joao ED, Chirinda P, Garrine M, Vubil D, Et al., Molecular epidemiology of rotavirus strains in symptomatic and asymptomatic children in manhiça district, Southern Mozambique 2008–2019, Viruses, 14, (2022)

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