Catalyst-Free, Radical Tri- and Difluoromethylation of Isocyanides and N-Arylacrylamides Using Rotating Magnetic Field and Metal Rods

被引：4

作者：

Han, Xuliang ^{[1
]}

Liu, Haodong ^{[1
]}

Feng, Xiaomei ^{[1
]}

Jia, Fuchao ^{[2
]}

Zhao, Zengdian ^{[1
]}

Li, Xinjin ^{[1
]}

机构：

[1] Shandong Univ Technol, Sch Chem & Chem Engn, Zibo 255000, Shandong, Peoples R China

[2] Shandong Univ Technol, Sch Phys & Optoelelctron Engn, Zibo 255000, Shandong, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2025年 / 43卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Trifluoromethylation; Difluoromethylation; Radical; Single-electron transfer; Catalyst-free; Magnetic field; Electromagnetic induction; Isocyanides; TRIFLUOROMETHYLATION; CYCLIZATION; FLUORINE;

D O I：

10.1002/cjoc.202400854

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pursuit of sustainable and environmentally benign synthetic methods continues to challenge organic chemists. Herein, we introduce a magnetoredox system for tri- and difluoromethylation of isocyanides and N-arylacrylamides using a rotating magnetic field and steel rods. This magnetoredox approach enables facile synthesis of functionalized phenanthridines and oxindoles without the need for catalysts and additives under mild conditions. Such a system potentially represents an attractive strategy for selective formation of bonds through multifaceted regulation of magnetic intensity, rotating frequency, and rod size.

引用

页码：155 / 160

页数：6

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