The different manifestations of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in evaluation of the steroid therapy response for IgG4-related disease: A case report

被引：1
作者：
Jia, Guorong [1 ]
Bian, Dejian [2 ]
Cheng, Chao [1 ]
Wang, Meitang [2 ]
Zuo, Changjing [1 ]
机构：
[1] Navy Mil Med Univ, Shanghai Changhai Hosp, Dept Nucl Med, Shanghai, Peoples R China
[2] Navy Mil Med Univ, Shanghai Changhai Hosp, Dept Emergency, Shanghai, Peoples R China
来源：
FRONTIERS IN NUCLEAR MEDICINE | 2023年 / 2卷
关键词：
F-18-FDG; Ga-68-FAPI-04; IgG4-related disease; PET/CT; therapy;
D O I：
10.3389/fnume.2022.1038797
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
IgG4-related disease is a fibrous-inflammatory process belonging to immunomodulation disorders. We report a case of a 57-year-old man with the IgG4-related disease (RD). Ga-68-FAPI-04 PET/CT showed more significant uptake in most lesions than in F-18-FDG PET/CT except for the cervical and mediastinal lymph nodes. Besides, uptake in the submandibular glands were only detected in Ga-68-FAPI-04 PET/CT. The biopsy result of the cervical lymph nodes confirmed the diagnosis of IgG4-related disease. After treatment, only slight FDG-avid cervical lymph nodes were observed in the F-18-FDG PET/CT, while the raised uptake of Ga-68-FAPI-04 could be observed in the pancreas and submandibular glands. Ga-68-FAPI-04 PET-CT might have promising applications in evaluating IgG4-RD, whether in initial or follow-up imaging during steroid therapy.
引用
收藏
页数：5
相关论文
共 15 条
[1]   Consensus statement on the pathology of IgG4-related disease [J].
Deshpande, Vikram ;
Zen, Yoh ;
Chan, John K. ;
Yi, Eunhee E. ;
Sato, Yasuharu ;
Yoshino, Tadashi ;
Kloeppel, Guenter ;
Heathcote, J. Godfrey ;
Khosroshahi, Arezou ;
Ferry, Judith A. ;
Aalberse, Rob C. ;
Bloch, Donald B. ;
Brugge, William R. ;
Bateman, Adrian C. ;
Carruthers, Mollie N. ;
Chari, Suresh T. ;
Cheuk, Wah ;
Cornell, Lynn D. ;
Fernandez-Del Castillo, Carlos ;
Forcione, David G. ;
Hamilos, Daniel L. ;
Kamisawa, Terumi ;
Kasashima, Satomi ;
Kawa, Shigeyuki ;
Kawano, Mitsuhiro ;
Lauwers, Gregory Y. ;
Masaki, Yasufumi ;
Nakanuma, Yasuni ;
Notohara, Kenji ;
Okazaki, Kazuich ;
Ryu, Ji Kon ;
Saeki, Takako ;
Sahani, Dushyant V. ;
Smyrk, Thomas C. ;
Stone, James R. ;
Takahira, Masayuki ;
Webster, George J. ;
Yamamoto, Motohisa ;
Zamboni, Giuseppe ;
Umehara, Hisanori ;
Stone, John H. .
MODERN PATHOLOGY, 2012, 25 (09) :1181-1192
[2]   18F-fluorodeoxyglucose PET and PET/computed tomography for the evaluation of immunoglobulin G4-related disease: a systematic review [J].
Dondi, Francesco ;
Albano, Domenico ;
Bellini, Pietro ;
Volpi, Giulia ;
Giubbini, Raffaele ;
Bertagna, Francesco .
NUCLEAR MEDICINE COMMUNICATIONS, 2022, 43 (06) :638-645
[3]   Prediction of malignant lymph nodes in NSCLC by machine-learning classifiers using EBUS-TBNA and PET/CT [J].
Guberina, Maja ;
Herrmann, Ken ;
Poettgen, Christoph ;
Guberina, Nika ;
Hautzel, Hubertus ;
Gauler, Thomas ;
Ploenes, Till ;
Umutlu, Lale ;
Wetter, Axel ;
Theegarten, Dirk ;
Aigner, Clemens ;
Eberhardt, Wilfried E. E. ;
Metzenmacher, Martin ;
Wiesweg, Marcel ;
Schuler, Martin ;
Karpf-Wissel, Ruediger ;
Garcia, Alina Santiago ;
Darwiche, Kaid ;
Stuschke, Martin .
SCIENTIFIC REPORTS, 2022, 12 (01)
[4]   Non-oncologic incidental uptake on FAPI PET/CT imaging [J].
Hotta, Masatoshi ;
Rieger, Angela C. ;
Jafarvand, Mahbod G. ;
Menon, Nandakumar ;
Farolfi, Andrea ;
Benz, Matthias R. ;
Calais, Jeremie .
BRITISH JOURNAL OF RADIOLOGY, 2023, 96 (1142)
[5]   IgG4-related disease [J].
Kamisawa, Terumi ;
Zen, Yoh ;
Pillai, Shiv ;
Stone, John H. .
LANCET, 2015, 385 (9976) :1460-1471
[6]   68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer [J].
Kratochwil, Clemens ;
Flechsig, Paul ;
Lindner, Thomas ;
Abderrahim, Labidi ;
Altmann, Annette ;
Mier, Walter ;
Adeberg, Sebastian ;
Rathke, Hendrik ;
Roehrich, Manuel ;
Winter, Hauke ;
Plinkert, Peter K. ;
Marme, Frederik ;
Lang, Matthias ;
Kauczor, Hans-Ulrich ;
Jaeger, Dirk ;
Debus, Juergen ;
Haberkorn, Uwe ;
Giesel, Frederik L. .
JOURNAL OF NUCLEAR MEDICINE, 2019, 60 (06) :801-805
[7]   Fibroblast Activation Protein-Targeted PET/CT with 68Ga-FAPI for Imaging IgG4-Related Disease: Comparison to 18F-FDG PET/CT [J].
Luo, Yaping ;
Pan, Qingqing ;
Yang, Huaxia ;
Peng, Linyi ;
Zhang, Wen ;
Li, Fang .
JOURNAL OF NUCLEAR MEDICINE, 2021, 62 (02) :266-271
[8]   Recurrent Immunoglobulin G4-Related Disease Shown on 18F-FDG and 68Ga-FAPI PET/CT [J].
Pan, Qingqing ;
Luo, Yaping ;
Zhang, Wen .
CLINICAL NUCLEAR MEDICINE, 2020, 45 (04) :312-313
[9]   IgG4-related disease: an update on pathophysiology and implications for clinical care [J].
Perugino, Cory A. ;
Stone, John H. .
NATURE REVIEWS RHEUMATOLOGY, 2020, 16 (12) :702-714
[10]   Immunoglobulin G4-Related Sclerosing Cholangitis Revealed by 68Ga-FAPI PET/MR [J].
Qin, Chunxia ;
Yang, Ling ;
Ruan, Weiwei ;
Shao, Fuqiang ;
Lan, Xiaoli .
CLINICAL NUCLEAR MEDICINE, 2021, 46 (05) :419-421
12