Potential Therapeutic Targets for Combination Antibody Therapy Against Staphylococcus aureus Infections

被引：0

作者：

Ke, Sharon ^{[1
]}

Kil, Hyein ^{[2
]}

Roggy, Conner ^{[3
]}

Shields, Ty ^{[1
]}

Quinn, Zachary ^{[1
]}

Quinn, Alyssa P. ^{[1
]}

Small, James M. ^{[1
]}

Towne, Francina D. ^{[1
]}

Brooks, Amanda E. ^{[1
]}

Brooks, Benjamin D. ^{[1
]}

机构：

[1] Rocky Vista Univ, Coll Osteopath Med, Dept Biomed Sci, Parker, CO 80134 USA

[2] Virtua Hlth, Dept Surg, Camden, NJ 08103 USA

[3] Dept Orthopaed Surg Community Mem Healthcare, Ventura, CA 93003 USA

来源：

ANTIBIOTICS-BASEL | 2024年 / 13卷 / 11期

关键词：

polyclonal antibodies; antibiotic resistance; antibiotics; combination therapies; MRSA; <italic>Staphylococcus aureus</italic>; immunotherapies; FIBRONECTIN-BINDING PROTEIN; MSCRAMM CLUMPING FACTOR; BACTERIAL ADHERENCE; CELLULAR INVASION; FACTOR-B; FACTOR-A; VACCINE; IDENTIFICATION; IMMUNIZATION; ADULTS;

D O I：

10.3390/antibiotics13111046

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Despite the significant advances in antibiotic treatments and therapeutics, Staphylococcus aureus (S. aureus) remains a formidable pathogen, primarily due to its rapid acquisition of antibiotic resistance. Known for its array of virulence factors, including surface proteins that promote adhesion to host tissues, enzymes that break down host barriers, and toxins that contribute to immune evasion and tissue destruction, S. aureus poses a serious health threat. Both the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) classify S. aureus as an ESKAPE pathogen, recognizing it as a critical threat to global health. The increasing prevalence of drug-resistant S. aureus underscores the need for new therapeutic strategies. This review discusses a promising approach that combines monoclonal antibodies targeting multiple S. aureus epitopes, offering synergistic efficacy in treating infections. Such strategies aim to reduce the capacity of the pathogen to develop resistance, presenting a potent adjunct or alternative to conventional antibiotic treatments.

引用

页数：25

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