pH-responsive zeolite-A/chitosan nanocarrier for enhanced ibuprofen drug delivery in gastrointestinal systems

Targeted drug delivery with responsive release is an emerging research area. Along this line, we report herein the fabrication and characterization of zeolite/chitosan (ZA/CS) composite as a pH-responsive drug carrier for ibuprofen. The drug loading and release, along with cytotoxicity, have been examined to assessing the effectiveness of ZA/CS composite as an ibuprofen therapeutic delivery system. The ZA/CS composite demonstrates a drug loading content (DLC) of 1989.13 mg/g and an entrapment efficiency content (EEC) of 99.88 %, as determined by drug loading. The released ibuprofen demonstrated virtually linear behavior in fluids that simulated the pH values of the gastrointestinal system. The release at pH 1.2 reached 55 % after 2 h. Seven kinetic models were tested to simulate the drug release process. The Ritger-Peppas model was determined to be the most suitable model. The estimated diffusion exponent (n) values were calculated to be 0.863 at pH 1.2 and 0.981 at pH 7.4, suggesting anomalous or non-Fickian diffusion mechanisms. Importantly, the ZA/CS composite exhibited excellent biocompatibility as demonstrated by a cytotoxicity evaluation using the MTT assay. These unique features render the examined ZA/CS composite a promising candidate for future targeted drug delivery applications.