Evaluation of central nervous system involvement in patients undergoing chimeric antigen receptor-engineered T-cell therapy by magnetic resonance imaging

被引:0
作者
Choque-Chavez, F. D. [1 ]
Jareno-Badenas, A. [1 ]
Benitez-Ribas, D. [2 ]
Oleaga, L. [1 ]
机构
[1] Hosp Clin Barcelona, Dept Radiol, Barcelona, Spain
[2] Hosp Clin Barcelona, Inmunol, Barcelona, Spain
来源
RADIOLOGIA | 2025年 / 67卷 / 01期
关键词
CAR-T; ICANS; Lymphoma; Neurotoxicity syndromes; NEUROTOXICITY;
D O I
10.1016/j.rx.2023.09.002
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Chimeric antigen receptor-engineered (CAR) T-cell therapy is an effective immunotherapy for aggressive hematologic cancers. However, it can lead to complications such immune effector cell-associated neurotoxicity syndrome (ICANS), or complications related
引用
收藏
页码:91 / 95
页数:5
相关论文
共 10 条
  • [1] Imaging Primer on Chimeric Antigen Receptor T-Cell Therapy for Radiologists
    de Groot, Patricia M.
    Arevalo, Octavio
    Shah, Komal
    Strange, Chad D.
    Shroff, Girish S.
    Ahuja, Jitesh
    Truong, Mylene T.
    de Groot, John F.
    Vlahos, Ioannis
    [J]. RADIOGRAPHICS, 2022, 42 (01) : 176 - 194
  • [2] Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells
    Gust, Juliane
    Hay, Kevin A.
    Hanafi, Laila-Aicha
    Li, Daniel
    Myerson, David
    Gonzalez-Cuyar, Luis F.
    Yeung, Cecilia
    Liles, W. Conrad
    Wurfel, Mark
    Lopez, Jose A.
    Chen, Junmei
    Chung, Dominic
    Harju-Baker, Susanna
    Tzpolat, Tahsin
    Fink, Kathleen R.
    Riddell, Stanley R.
    Maloney, David G.
    Turtle, Cameron J.
    [J]. CANCER DISCOVERY, 2017, 7 (12) : 1404 - 1419
  • [3] Immune effector cell-associated neurotoxicity syndrome after chimeric antigen receptor T-cell therapy for lymphoma: predictive biomarkers and clinical outcomes
    Holtzman, Noa G.
    Xie, Hao
    Bentzen, Soren
    Kesari, Vivek
    Bukhari, Ali
    El Chaer, Firas
    Lutfi, Forat
    Siglin, Jonathan
    Hutnick, Elizabeth
    Gahres, Natalie
    Ruehle, Kathleen
    Ahmad, Haroon
    Shanholtz, Carl
    Kocoglu, Mehmet H.
    Badros, Ashraf Z.
    Yared, Jean A.
    Hardy, Nancy M.
    Rapoport, Aaron P.
    Dahiya, Saurabh
    [J]. NEURO-ONCOLOGY, 2021, 23 (01) : 112 - 121
  • [4] Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells
    Karschnia, Philipp
    Jordan, Justin T.
    Forst, Deborah A.
    Arrillaga-Romany, Isabel C.
    Batchelor, Tracy T.
    Baehring, Joachim M.
    Clement, Nathan F.
    Castro, L. Nicolas Gonzalez
    Herlopian, Aline
    Maus, Marcela, V
    Schwaiblmair, Michaela H.
    Soumerai, Jacob D.
    Takvorian, Ronald W.
    Hochberg, Ephraim P.
    Barnes, Jeffrey A.
    Abramson, Jeremy S.
    Frigault, Matthew J.
    Dietrich, Jorg
    [J]. BLOOD, 2019, 133 (20) : 2212 - 2221
  • [5] ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells
    Lee, Daniel W.
    Santomasso, Bianca D.
    Locke, Frederick L.
    Ghobadi, Armin
    Turtle, Cameron J.
    Brudno, Jennifer N.
    Maus, Marcela, V
    Park, Jae H.
    Mead, Elena
    Pavletic, Steven
    Go, William Y.
    Eldjerou, Lamis
    Gardner, Rebecca A.
    Frey, Noelle
    Curran, Kevin J.
    Peggs, Karl
    Pasquini, Marcelo
    DiPersio, John F.
    van den Brink, Marcel R. M.
    Komanduri, Krishna, V
    Grupp, Stephan A.
    Neelapu, Sattva S.
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2019, 25 (04) : 625 - 638
  • [6] Chimeric Antigen Receptor T Cell-Related Neurotoxicity: Mechanisms, Clinical Presentation, and Approach to Treatment
    Rice, Jessica
    Nagel, Sarah
    Randall, Julie
    Hinson, Holly E.
    [J]. CURRENT TREATMENT OPTIONS IN NEUROLOGY, 2019, 21 (08)
  • [7] Neurological toxicities associated with chimeric antigen receptor T-cell therapy
    Rubin, Daniel B.
    Danish, Husain H.
    Ali, Ali Basil
    Li, Karen
    LaRose, Sarah
    Monk, Andrew D.
    Cote, David J.
    Spendley, Lauren
    Kim, Angela H.
    Robertson, Matthew S.
    Torre, Matthew
    Smith, Timothy R.
    Izzy, Saef
    Jacobson, Caron A.
    Lee, Jong Woo
    Vaitkevicius, Henrikas
    [J]. BRAIN, 2019, 142 : 1334 - 1348
  • [8] Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia
    Santomasso, Bianca D.
    Park, Jae H.
    Salloum, Darin
    Riviere, Isabelle
    Flynn, Jessica
    Mead, Elena
    Halton, Elizabeth
    Wang, Xiuyan
    Senechal, Brigitte
    Purdon, Terence
    Cross, Justin R.
    Liu, Hui
    Vachha, Behroze
    Chen, Xi
    DeAngelis, Lisa M.
    Li, Daniel
    Bernal, Yvette
    Gonen, Mithat
    Wendel, Hans-Guido
    Sadelain, Michel
    Brentjens, Renier J.
    [J]. CANCER DISCOVERY, 2018, 8 (08) : 958 - 971
  • [9] Imaging-based Toxicity and Response Pattern Assessment Following CAR T-Cell Therapy
    Smith, Daniel A.
    Kikano, Elias
    Tirumani, Sree Harasha
    de Lima, Marcos
    Caimi, Paolo
    Ramaiya, Nikhil H.
    [J]. RADIOLOGY, 2022, 302 (02) : 438 - 445
  • [10] CAR T-Cell Therapy: An Update for Radiologists
    Yoon, Justin G.
    Smith, Daniel A.
    Tirumani, Sree H.
    Caimi, Paolo F.
    Ramaiya, Nikhil H.
    [J]. AMERICAN JOURNAL OF ROENTGENOLOGY, 2021, 217 (06) : 1461 - 1474