FEATURES OF INTRAUTERINE MICROBIOTA IN PATIENTS WITH ENDOMETRIAL POLYPS

被引：0

作者：

Vanakova, A., I ^{[1
,2
]}

Dolgushina, N., V ^{[1
,2
]}

Denisov, P. A. ^{[1
]}

Goncharuk, O. D. ^{[1
]}

Muravieva, V. V. ^{[1
]}

Priputnevich, T., V ^{[1
]}

机构：

[1] Kulakov Natl Med Res Ctr Obstet Gynecol & Perinato, Moscow, Russia

[2] Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow, Russia

来源：

BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY | 2025年 / 01期

关键词：

intrauterine microbiota; cervical canal microbiota; endometrial polyps; REPRODUCTIVE-TRACT; HYSTEROSCOPY; OUTCOMES; CAVITY; WOMEN;

D O I：

10.24075/brsmu.2025.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endometrial polyps (EPs) represent the most common form of benign intrauterine disorder. Microbial factor is one of the possible etiological factors of EPs. Investigation of endometrial microbiota can provide new opportunities for improvement of the EP diagnosis and treatment. The study is aimed to assess intrauterine microbiota composition in patients with endometrial polyps. A total of 84 patients with endometrial polyps based on histology assessment data were enrolled. The comparison group included 44 patients having no endometrial abnormality. Endometrial microbiota composition was assessed by the culturomics method using the extended set of selective and nonselective growth media. The endometrium sample was obtained before performing hysteroresectoscopy. In patients with EP, growth of bacterial microflora in the uterine cavity was observed 2.4 times more often compared to patients having no endometrial abnormality (OR - 2.4, 95% CI - 1.1; 5.5). In cases of EP, intrauterine microbiota composition was characterized by larger species and taxonomic diversity. Microorganisms of the genera Staphylococcus and Lactobacilus prevailed. Further research focused on endometrial microecology can provide new opportunities for further improvement of the EP diagnosis and treatment strategies.

引用

页码：35 / 41

页数：7

共 32 条

[1] Long-Term Outcomes After Intrauterine Morcellation vs Hysteroscopic Resection of Endometrial Polyps [J].

AlHilli, Mariam M. ;

Nixon, Kayla E. ;

Hopkins, Matthew R. ;

Weaver, Amy L. ;

Laughlin-Tommaso, Shannon K. ;

Famuyide, Abimbola O. .

JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, 2013, 20 (02) :215-221

[2] STERILITY OF UTERINE CAVITY [J].

ANSBACHE.R ;

BOYSON, WA ;

MORRIS, JA .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1967, 99 (03) :394-&

[3] The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases [J].

Chen, Chen ;

Song, Xiaolei ;

Wei, Weixia ;

Zhong, Huanzi ;

Dai, Juanjuan ;

Lan, Zhou ;

Li, Fei ;

Yu, Xinlei ;

Feng, Qiang ;

Wang, Zirong ;

Xie, Hailiang ;

Chen, Xiaomin ;

Zeng, Chunwei ;

Wen, Bo ;

Zeng, Liping ;

Du, Hui ;

Tang, Huiru ;

Xu, Changlu ;

Xia, Yan ;

Xia, Huihua ;

Yang, Huanming ;

Wang, Jian ;

Wang, Jun ;

Madsen, Lise ;

Brix, Susanne ;

Kristiansen, Karsten ;

Xu, Xun ;

Li, Junhua ;

Wu, Ruifang ;

Jia, Huijue .

NATURE COMMUNICATIONS, 2017, 8

[4] Chronic Endometritis, a Common Disease Hidden Behind Endometrial Polyps in Premenopausal Women: First Evidence From a Case-Control Study [J].

Cicinelli, Ettore ;

Bettocchi, Stefano ;

de Ziegler, Dominique ;

Loizzi, Vera ;

Cormio, Gennaro ;

Marinaccio, Marco ;

Trojano, Giuseppe ;

Crupano, Francesco Maria ;

Francescato, Roberta ;

Vitagliano, Amerigo ;

Resta, Leonardo .

JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, 2019, 26 (07) :1346-1350

[5] Poor Reliability of Vaginal and Endocervical Cultures for Evaluating Microbiology of Endometrial Cavity in Women with Chronic Endometritis [J].

Cicinelli, Ettore ;

De Ziegler, Dominique ;

Nicoletti, Roberto ;

Tinelli, Raffaele ;

Saliani, Nicola ;

Resta, Leonardo ;

Bellavia, Marina ;

De Vito, Danila .

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2009, 68 (02) :108-115

[6] Endometrial Polyps and Abnormal Uterine Bleeding (AUB-P): What is the relationship, how are they diagnosed and how are they treated? [J].

Clark, T. Justin ;

Stevenson, Helen .

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2017, 40 :89-104

[7] Menstruation: science and society [J].

Critchley, Hilary O. D. ;

Babayev, Elnur ;

Bulun, Serdar E. ;

Clark, Sandy ;

Garcia-Grau, Iolanda ;

Gregersen, Peter K. ;

Kilcoyne, Aoife ;

Kim, Ji-Yong Julie ;

Lavender, Missy ;

Marsh, Erica E. ;

Matteson, Kristen A. ;

Maybin, Jacqueline A. ;

Metz, Christine N. ;

Moreno, Inmaculada ;

Silk, Kami ;

Sommer, Marni ;

Simon, Carlos ;

Tariyal, Ridhi ;

Taylor, Hugh S. ;

Wagner, Gunter P. ;

Griffith, Linda G. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2020, 223 (05) :624-664

[8]

Fang RL, 2016, AM J TRANSL RES, V8, P1581

[9] Prevalence of unsuspected uterine cavity abnormalities diagnosed by office hysteroscopy prior to in vitro fertilization [J].

Fatemi, H. M. ;

Kasius, J. C. ;

Timmermans, A. ;

van Disseldorp, J. ;

Fauser, B. C. ;

Devroey, P. ;

Broekmans, F. J. .

HUMAN REPRODUCTION, 2010, 25 (08) :1959-1965

[10] Endometrial microbiome at the time of embryo transfer: next-generation sequencing of the 16S ribosomal subunit [J].

Franasiak, J. M. ;

Werner, M. D. ;

Juneau, C. R. ;

Tao, X. ;

Landis, J. ;

Zhan, Y. ;

Treff, N. R. ;

Scott, R. T. .

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2016, 33 (01) :129-136

← 1 2 3 4 →