FEATURES OF INTRAUTERINE MICROBIOTA IN PATIENTS WITH ENDOMETRIAL POLYPS

被引：0
作者：
Vanakova, A., I [1 ,2 ]
Dolgushina, N., V [1 ,2 ]
Denisov, P. A. [1 ]
Goncharuk, O. D. [1 ]
Muravieva, V. V. [1 ]
Priputnevich, T., V [1 ]
机构：
[1] Kulakov Natl Med Res Ctr Obstet Gynecol & Perinato, Moscow, Russia
[2] Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow, Russia
来源：
BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY | 2025年 / 01期
关键词：
intrauterine microbiota; cervical canal microbiota; endometrial polyps; HYSTEROSCOPY; OUTCOMES; CAVITY; WOMEN;
D O I：
10.24075/brsmu.2025.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Endometrial polyps (EPs) represent the most common form of benign intrauterine disorder. Microbial factor is one of the possible etiological factors of EPs. Investigation of endometrial microbiota can provide new opportunities for improvement of the EP diagnosis and treatment. The study is aimed to assess intrauterine microbiota composition in patients with endometrial polyps. A total of 84 patients with endometrial polyps based on histology assessment data were enrolled. The comparison group included 44 patients having no endometrial abnormality. Endometrial microbiota composition was assessed by the culturomics method using the extended set of selective and nonselective growth media. The endometrium sample was obtained before performing hysteroresectoscopy. In patients with EP, growth of bacterial microflora in the uterine cavity was observed 2.4 times more often compared to patients having no endometrial abnormality (OR - 2.4, 95% CI - 1.1; 5.5). In cases of EP, intrauterine microbiota composition was characterized by larger species and taxonomic diversity. Microorganisms of the genera Staphylococcus and Lactobacilus prevailed. Further research focused on endometrial microecology can provide new opportunities for further improvement of the EP diagnosis and treatment strategies.
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页码：35 / 41
页数：7
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