The natural course of newborns with transient congenital hypothyroidism

被引:0
作者
Almagor, Tal [1 ]
Almashanu, Shlomo [2 ]
Elias-Assad, Ghadir [3 ]
Admoni, Osnat [3 ]
Ludar, Hanna [4 ]
London, Shira [4 ]
Rath, Shoshana [3 ,5 ]
German, Alina [1 ]
Shwartz, Naama [6 ]
Tenenbaum-Rakover, Yardena [7 ,8 ]
机构
[1] HaEmek Med Ctr, Pediat Endocrine Inst, Afula, Israel
[2] Minist Hlth, Natl Newborn Screening Program, Ramat Gan, Israel
[3] Clalit Hlth Serv, Pediat Endocrine Ctr, Tel Aviv, Northern Region, Israel
[4] Clalit Hlth Serv, Pediat Hlth Ctr, Haifa, Israel
[5] Northern Hlth Ctr, Pediat Endocrinol Serv, Poria, Israel
[6] Carmel Hosp, Dept Epidemiol, Haifa, Israel
[7] Technion, Ruth & Bruce Rappaport Fac Med, Haifa, Israel
[8] Clalit Hlth Serv, Childrens Endocrinol Consulting Ctr, Afula, Israel
关键词
congenital hypothyroidism; transient congenital hypothyroidism; permanent congenital hypothyroidism; newborn screening; thyroid function tests; RECEPTOR-BLOCKING ANTIBODIES; 3-YEAR FOLLOW-UP; SCREENING-PROGRAM; THYROID-FUNCTION; NEW-YORK; PERMANENT; CHILDREN; HYPERTHYROTROPINEMIA; ETIOLOGY; ENDOCRINOLOGY;
D O I
10.1530/EC-24-0316
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives The incidence of congenital hypothyroidism (CH) has increased worldwide over the last decades, mainly due to the lowering of screening thresholds, resulting in the increased identification of newborns with transient CH. Several studies have reported the prevalence and the predictive parameters of transient CH, but reports on the long-term outcome are rare. This study aimed to assess the long-term course of neonates with transient CH.Design Neonates diagnosed with transient and permanent CH between the years 1998 and 2018 at the Pediatric Endocrine Institute of Ha'Emek Medical Center were enrolled in the study. Data were retrieved retrospectively from medical files.Results A total of 76 newborns (45M, 59%) with transient CH and 53 (25M, 47%) with permanent CH were included in the study. The major causes of transient CH were prematurity (29%) and subclinical hypothyroidism (30%). During retrospective follow-ups of up to 23 years, reinitiation of levothyroxine therapy was not required, apart from four patients with underlying syndromic etiologies. Neurodevelopmental impairment occurred in 16% of children with transient CH compared with 29.4% in the permanent CH group.Conclusions Transient CH is frequent among preterm infants but is generally limited to infancy. Subclinical hypothyroidism frequently presents as overt hypothyroidism at birth, but in most cases, the requirement for levothyroxine supplemental therapy is limited to the first years of life, suggesting that long-term follow-up of thyroid function tests may be unnecessary for non-syndromic children. The high rate of neurodevelopmental impairment in newborns with transient CH emphasizes the need for neurodevelopmental monitoring in these patients.Significance statement A high rate of transient CH has been identified over the past decades following the lowering of TSH screening thresholds. The long-term outcome of transient CH has been evaluated in a few studies with inconclusive results. In the current study, we assessed the long-term outcomes of transient CH for up to 23 years. We found that 29% of cases were attributed to prematurity and 30% to subclinical hypothyroidism. No morphological anomalies were identified. Only syndromic patients (three with Down syndrome and one with Coffin-Lowry syndrome) required levothyroxine supplemental therapy at the time of the study, indicating that long-term thyroid function monitoring may be unnecessary. The high prevalence of neurodevelopmental impairment suggests the need for close neurodevelopmental monitoring in this population.
引用
收藏
页数:9
相关论文
共 50 条
[31]   Newborn Screening for Congenital Hypothyroidism in Japan [J].
Minamitani, Kanshi .
INTERNATIONAL JOURNAL OF NEONATAL SCREENING, 2021, 7 (03)
[32]   Transient vs Permanent Congenital Hypothyroidism in Ontario, Canada: Predictive Factors and Scoring System [J].
Marr, Alexa ;
Yokubynas, Nicole ;
Tang, Ken ;
Saleh, David ;
Wherrett, Diane K. ;
Stein, Robert ;
Bassilious, Ereny ;
Chakraborty, Pranesh ;
Lawrence, Sarah E. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022, 107 (03) :638-648
[33]   Permanent vs Transient Congenital Hypothyroidism: Assessment of Predictive Variables [J].
Oron, Tal ;
Lazar, Liora ;
Ben-Yishai, Shimon ;
Tenenbaum, Ariel ;
Yackobovitch-Gavan, Michal ;
Meyerovitch, Joseph ;
Phillip, Moshe ;
Lebenthal, Yael .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2018, 103 (12) :4428-4436
[34]   Redefining Congenital Hypothyroidism? [J].
Van Vliet, Guy ;
Escagedo, Patricia Diaz .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2021, 106 (03) :E1463-E1465
[35]   Screening for congenital hypothyroidism: A worldwide view of strategies [J].
Ford, George ;
LaFranchi, Stephen H. .
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 28 (02) :175-187
[36]   Unbalanced long-chain fatty acid beta-oxidation in newborns with cystic fibrosis and congenital hypothyroidism [J].
Pinnaro, Catherina T. ;
Ryckman, Kelli K. ;
Uc, Aliye ;
Norris, Andrew W. .
MOLECULAR GENETICS AND METABOLISM REPORTS, 2025, 42
[37]   Prevalence of transient congenital hypothyroidism among neonates [J].
Alavi, Ezatollah Rafiei ;
Rafiei, Niloofar ;
Rafiei, Romina ;
Farokhi, Ermia .
ANNALS OF MEDICINE AND SURGERY, 2021, 72
[38]   Transient congenital hypothyroidism- A Rare Case [J].
Singh, Manish Kumar ;
Tondon, Pushpa ;
Gupta, Ashish ;
Natu, S. M. ;
Ali, Wahid ;
Mehrotra, Raj .
BIOMEDICAL RESEARCH-INDIA, 2011, 22 (04) :519-521
[39]   Congenital Hypothyroidism in Preterm Newborns - The Challenges of Diagnostics and Treatment: A Review [J].
Klosinska, Martyna ;
Kaczynska, Agnieszka ;
Ben-Skowronek, Iwona .
FRONTIERS IN ENDOCRINOLOGY, 2022, 13
[40]   Prevalence of congenital hypothyroidism in newborns in Khorasan Razavi province, Iran [J].
Javad, Hoseini Seyed ;
Majid, Ghayour-Mobarhan ;
Morteza, Ehteshamfar Seyed ;
Hasan, Khodaee Gholam ;
Hosein, Khooban ;
Hasan, Boskabadi ;
Fatemeh, Kiani .
CLINICAL BIOCHEMISTRY, 2011, 44 (13) :S64-S64