The impact of donor-specific antibody and non-HLA antibodies on acute cellular rejection in pediatric liver transplantation

被引：1

作者：

Xu, Qingyong ^{[1
]}

Bedoyan, Sarah M. ^{[2
]}

Bentlejewski, Carol ^{[1
]}

Sindhi, Rakesh ^{[3
,4
]}

Mazariegos, George, V ^{[3
,4
]}

Zeevi, Adriana ^{[1
]}

Squires, James E. ^{[2
]}

机构：

[1] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA

[2] UPMC Childrens Hosp Pittsburgh, Dept Pediat, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA

[4] UPMC Childrens Hosp Pittsburgh, Thomas E Starzl Transplantat Inst, Hillman Ctr Pediat Transplantat, Pittsburgh, PA USA

来源：

HUMAN IMMUNOLOGY | 2025年 / 86卷 / 03期

关键词：

Non-HLA antibody; Donor-specific antibody; Human leukocyte antigen; Liver transplantation; Rejection; ALLOANTIBODIES;

D O I：

10.1016/j.humimm.2025.111289

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibodies to HLA or non-HLA antigens are associated with detrimental outcomes in organ transplants. Here, we aim to examine whether donor-specific antibodies (DSA) and non-HLA antibodies are associated with rejection in a single-center cohort of 101 pediatric liver transplant (PLTx) recipients. Rejection was found in 50/101 biopsies (49.5 %). DSA was positive in 32 paired sera and associated with rejection (HR = 2.63[1.10-6.30]). Antibodies to 3 non-HLA antigens, SNRPB (small nuclear ribonucleoprotein polypeptides B), GSTT1 (Glutathione S-transferase theta-1), and Actin were associated with rejection. Rejection was found in 22/35 cases positive for any of the three non-HLA antibodies. The presence of DSA and non-HLA antibodies was associated with an augmented risk of rejection (HR = 6.32[1.57-25.30], p < 0.01]. In conclusion, DSA or non-HLA antibodies were associated with a higher risk for rejection in PLTx recipients. When they were detected concomitantly, the risk for rejection increased significantly, indicating the synergistic effect of actions.

引用

页数：5

共 14 条

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