Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions

被引：3

作者：

Gajagowni, Saivaroon ^{[1
]}

Hopkins, Steven ^{[1
]}

Qadeer, Yusuf ^{[1
]}

Virani, Salim S. ^{[2
,3
]}

Verdonschot, Job A. J. ^{[4
]}

Coombs, Catherine C. ^{[5
]}

Amos, Christopher I. ^{[6
]}

Nead, Kevin T. ^{[7
,8
]}

Jaiswal, Siddhartha ^{[9
]}

Krittanawong, Chayakrit ^{[10
,11
]}

机构：

[1] Baylor Coll Med, Dept Med, Houston, TX USA

[2] Aga Khan Univ, Off Vice Provost Res, Karachi 74800, Pakistan

[3] Baylor Coll Med, Dept Med, Sect Cardiol & Cardiovasc Res, Houston, TX 77030 USA

[4] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht CARIM, Ctr Heart Failure Res,Dept Cardiol,Univ Hosp Maast, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands

[5] Univ Calif Irvine, Dept Med, Div Hematol Oncol, Irvine, CA USA

[6] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Houston, TX USA

[7] Univ Texas Md Anderson Canc Ctr, Dept Epidemiol, Houston, TX USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX USA

[9] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA USA

[10] NYU Langone Hlth, Cardiol Div, New York, NY USA

[11] NYU, Sch Med, New York, NY USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2024年 / 86卷

关键词：

CHIP; Clonal hematopoiesis of indeterminate; potential; Atherosclerosis; Cardiovascular complications; TET2; ATHEROSCLEROSIS; DNMT3A; RISK; ASSOCIATION; INHIBITION; MUTATIONS;

D O I：

10.1016/j.pcad.2024.09.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clonal hematopoiesis of indeterminate potential (CHIP) is a well-studied phenomenon in hematologic malignancies. With advancements in gene sampling and analysis and the use of large cohort studies, CHIP has recently been linked to cardiovascular disease (CVD). The relationship between CHIP and CVD appears to be bidirectional, with traditional risk factors for cardiovascular disease increasing the mutation burden in CHIP, and CHIP itself effecting the incidence or prognosis of a variety of CVD. The purpose of this review is to understand the epidemiology, risk factors, and pathogenesis of CHIP in the context of various CVD conditions.

引用

页码：79 / 85

页数：7

共 57 条

[1] Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure [J].

Abplanalp, Wesley Tyler ;

Cremer, Sebastian ;

John, David ;

Hoffmann, Jedrzej ;

Schuhmacher, Bianca ;

Merten, Maximillian ;

Rieger, Michael A. ;

Vasa-Nicotera, Mariuca ;

Zeiher, Andreas M. ;

Dimmeler, Stefanie .

CIRCULATION RESEARCH, 2021, 128 (02) :216-228

[2]

Ahn HJ, 2023, Eur Heart J, V44, DOI [10.1093/eurheartj/ehad655.413, DOI 10.1093/EURHEARTJ/EHAD655.413]

[3] Clonal Hematopoiesis of Indeterminate Potential Is Associated With Coronary Microvascular Dysfunction In Early Nonobstructive Coronary Artery Disease [J].

Akhiyat, Nadia ;

Lasho, Terra ;

Ganji, Morsaleh ;

Toya, Takumi ;

Shi, Chang-Xin ;

Chen, Xianfeng ;

Braggio, Esteban ;

Ahmad, Ali ;

Corban, Michel T. ;

Stewart, Keith ;

Fernandez, Jenna ;

Xie, Zhuoer ;

Finke, Christy ;

Lerman, Lilach O. ;

Patnaik, Mrinal M. ;

Lerman, Amir .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 43 (05) :774-783

[4] Trend analysis of cardiovascular disease mortality, incidence, and mortality-to-incidence ratio: results from global burden of disease study 2017 [J].

Amini, Maedeh ;

Zayeri, Farid ;

Salehi, Masoud .

BMC PUBLIC HEALTH, 2021, 21 (01)

[5] Clonal Hematopoiesis Is Associated With Higher Risk of Stroke [J].

Bhattacharya, Romit ;

Zekavat, Seyedeh M. ;

Haessler, Jeffrey ;

Fornage, Myriam ;

Raffield, Laura ;

Uddin, Md Mesbah ;

Bick, Alexander G. ;

Niroula, Abhishek ;

Yu, Bing ;

Gibson, Christopher ;

Griffin, Gabriel ;

Morrison, Alanna C. ;

Psaty, Bruce M. ;

Longstreth, William T. ;

Bis, Joshua C. ;

Rich, Stephen S. ;

Rotter, Jerome, I ;

Tracy, Russell P. ;

Correa, Adolfo ;

Seshadri, Sudha ;

Johnson, Andrew ;

Collins, Jason M. ;

Hayden, Kathleen M. ;

Madsen, Tracy E. ;

Ballantyne, Christie M. ;

Jaiswal, Siddhartha ;

Ebert, Benjamin L. ;

Kooperberg, Charles ;

Manson, JoAnn E. ;

Whitsel, Eric A. ;

Natarajan, Pradeep ;

Reiner, Alexander P. .

STROKE, 2022, 53 (03) :788-797

[6] Short-Term Western Diet Causes Rapid and Lasting Alterations of Bone Marrow Physiology [J].

Bianchini, Mariaelvy ;

Moeller-Ramon, Zoe ;

Weber, Christian ;

Megens, Remco T. A. ;

Duchene, Johan .

THROMBOSIS AND HAEMOSTASIS, 2023, 123 (11) :1100-1104

[7]

Bick AG, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-021-04308-2

[8] Inherited causes of clonal haematopoiesis in 97,691 whole genomes [J].

Bick, Alexander G. ;

Weinstock, Joshua S. ;

Nandakumar, Satish K. ;

Fulco, Charles P. ;

Bao, Erik L. ;

Zekavat, Seyedeh M. ;

Szeto, Mindy D. ;

Liao, Xiaotian ;

Leventhal, Matthew J. ;

Nasser, Joseph ;

Chang, Kyle ;

Laurie, Cecelia ;

Burugula, Bala Bharathi ;

Gibson, Christopher J. ;

Lin, Amy E. ;

Taub, Margaret A. ;

Aguet, Francois ;

Ardlie, Kristin ;

Mitchell, Braxton D. ;

Barnes, Kathleen C. ;

Moscati, Arden ;

Fornage, Myriam ;

Redline, Susan ;

Psaty, Bruce M. ;

Silverman, Edwin K. ;

Weiss, Scott T. ;

Palmer, Nicholette D. ;

Vasan, Ramachandran S. ;

Burchard, Esteban G. ;

Kardia, Sharon L. R. ;

He, Jiang ;

Kaplan, Robert C. ;

Smith, Nicholas L. ;

Arnett, Donna K. ;

Schwartz, David A. ;

Correa, Adolfo ;

de Andrade, Mariza ;

Guo, Xiuqing ;

Konkle, Barbara A. ;

Custer, Brian ;

Peralta, Juan M. ;

Gui, Hongsheng ;

Meyers, Deborah A. ;

McGarvey, Stephen T. ;

Chen, Ida Yii-Der ;

Shoemaker, M. Benjamin ;

Peyser, Patricia A. ;

Broome, Jai G. ;

Gogarten, Stephanie M. ;

Wang, Fei Fei .

NATURE, 2020, 586 (7831) :763-+

[9] Cancer therapy shapes the fitness landscape of clonal hematopoiesis [J].

Bolton, Kelly L. ;

Ptashkin, Ryan N. ;

Gao, Teng ;

Braunstein, Lior ;

Devlin, Sean M. ;

Kelly, Daniel ;

Patel, Minal ;

Berthon, Antonin ;

Syed, Aijazuddin ;

Yabe, Mariko ;

Coombs, Catherine C. ;

Caltabellotta, Nicole M. ;

Walsh, Mike ;

Offit, Kenneth ;

Stadler, Zsofia ;

Mandelker, Diana ;

Schulman, Jessica ;

Patel, Akshar ;

Philip, John ;

Bernard, Elsa ;

Gundem, Gunes ;

Ossa, Juan E. Arango ;

Levine, Max ;

Martinez, Juan S. Medina ;

Farnoud, Noushin ;

Glodzik, Dominik ;

Li, Sonya ;

Robson, Mark E. ;

Lee, Choonsik ;

Pharoah, Paul D. P. ;

Stopsack, Konrad H. ;

Spitzer, Barbara ;

Mantha, Simon ;

Fagin, James ;

Boucai, Laura ;

Gibson, Christopher J. ;

Ebert, Benjamin L. ;

Young, Andrew L. ;

Druley, Todd ;

Takahashi, Koichi ;

Gillis, Nancy ;

Ball, Markus ;

Padron, Eric ;

Hyman, David M. ;

Baselga, Jose ;

Norton, Larry ;

Gardos, Stuart ;

Klimek, Virginia M. ;

Scher, Howard ;

Bajorin, Dean .

NATURE GENETICS, 2020, 52 (11) :1219-+

[10] Clonal Hematopoiesis Mutations Are Present in Atherosclerotic Lesions in Peripheral Artery Disease [J].

Buettner, Petra ;

Boettner, Julia ;

Krohn, Knut ;

Baber, Ronny ;

Platzbecker, Uwe ;

Cross, Michael ;

Desch, Steffen ;

Thiele, Holger ;

Steiner, Sabine ;

Scheinert, Dierk ;

Metzeler, Klaus H. ;

Branzan, Daniela .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (04)

← 1 2 3 4 5 6 →