Methylation Biomarkers of Lung Cancer Risk: A Systematic Review and Meta-Analysis

被引:0
|
作者
Dolcini, Jacopo [1 ]
Chiavarini, Manuela [2 ]
Firmani, Giorgio [1 ]
Brennan, Kasey J. M. [3 ]
Cardenas, Andres [4 ]
Baccarelli, Andrea A. [3 ]
Barbadoro, Pamela [1 ]
机构
[1] Polytech Univ Marche Reg, Dept Biomed Sci & Publ Hlth, Sect Hyg Prevent Med & Publ Hlth, I-60126 Ancona, Italy
[2] Univ Florence, Dept Hlth Sci, I-50134 Florence, Italy
[3] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
[4] Stanford Univ, Dept Epidemiol & Populat Hlth, Palo Alto, CA 94305 USA
关键词
lung cancer; DNA methylation; blood; meta-analysis; systematic review; epigenetic age; public health; DNA METHYLATION; EPIGENETIC AGE; DOSE-RESPONSE; MORTALITY; BREAST; ACCELERATION; PATTERNS; MARKER; SEX;
D O I
10.3390/cancers17040690
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Lung cancer (LC) is the leading cause of cancer deaths worldwide among both men and women, and represents a major public health challenge. DNA methylation (DNAm) has shown potential in identifying individuals at higher risk of LC, but the overall evidence has not been systematically evaluated. This review and meta-analysis aims to evaluate and summarize existing research on the association between blood DNAm levels and LC risk. Methods: Searches were conducted in PubMed, Web of Science, and Scopus for studies published until February 2024, following PRISMA and MOOSE guidelines. Eleven studies met the eligibility criteria. Results: Using a random effects model, our pooled analysis showed a significant association between increased DNAm levels and LC risk (OR 1.24, 95% CI 1.10-1.39; I2 = 93.90%, p = 0.0001). Stratifying the results by study design showed a stronger association in two prospective cohort studies (OR 1.61; 95% CI 1.36-1.90; I2 = 14.42%, p = 0.32), while case-control studies showed a weaker association (OR 1.05; 95% CI 0.99-1.11; I2 = 70.57%, p = 0.0001). Sensitivity analyses indicated that omitting individual studies did not significantly alter the LC risk estimates. Conclusions: These findings suggest that higher blood DNAm levels are associated with an increased risk of LC, especially in long-term cohort studies. Further research is recommended to explore the potential of DNAm as a screening biomarker for LC and to clarify the role of other influencing factors.
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页数:17
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