Concurrent Tumor-Treating Fields and Chemoradiotherapy: Outcomes in Grade 4 Glioma Patients

被引：0

作者：

Li, Jintan ^{[1
]}

Tao, Jincheng ^{[1
]}

Lu, Hongyu ^{[1
]}

Fan, Xiao ^{[1
]}

Wang, Zhichao ^{[1
]}

Wang, Yingyi ^{[1
]}

Wang, Xiefeng ^{[1
]}

Yan, Wei ^{[1
]}

You, Yongping ^{[1
,3
]}

Cao, Yuandong ^{[2
,3
]}

Zhang, Junxia ^{[1
,3
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Nanjing 210000, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Nanjing 210000, Peoples R China

[3] Nanjing Med Univ, Inst Brain Tumors, Jiangsu Collaborat Innovat Ctr Canc Personalized M, Nanjing, Peoples R China

来源：

CLINICAL MEDICINE INSIGHTS-ONCOLOGY | 2025年 / 19卷

关键词：

TTFields; WHO grade 4 gliomas; concurrent chemoradiotherapy; efficacy; toxicity; TEMOZOLOMIDE;

D O I：

10.1177/11795549251315579

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Surgical intervention, complemented by radiotherapy and chemotherapy with temozolomide, constitutes the conventional treatment protocol for patients with newly diagnosed grade 4 glioma. We have conducted a research to evaluate the efficacy and safety of an integrated treatment regimen that incorporates tumor-treating fields with concurrent chemoradiotherapy.Methods: This retrospective research analyzed the clinical data of 39 adults who were newly diagnosed with World Health Organization (WHO) grade 4 gliomas at the First Affiliated Hospital of Nanjing Medical University, between February 2022 and April 2023. Each participant received a concurrent treatment regimen consisting of temozolomide (75 mg/m2 daily), tumor-treating fields (200 kHz), and brain irradiation (60 Gy delivered in 30 fractions). Maintenance treatment comprised ongoing temozolomide and tumor-treating fields. Adverse events were documented in accordance with the Common Terminology Criteria for Adverse Events version 5.0 (CTCAE 5.0) and specific grading criteria for dermatological adverse events associated with tumor-treating fields.Results: Among the 39 enrolled patients, disease progression was observed in 22 individuals (56.4%), with a median progression-free survival (PFS) of 14.2 months (95% confidence interval [CI]: 13.1-14.3 months). The median overall survival (OS) was 18.2 months (95% CI: 17.3 months to not reached). Patients diagnosed with glioblastoma had a median PFS of 13.1 months (95% CI: 12.9-14.2 months) and a median OS of 18.2 months (95% CI: 17.3 months to not reached). In contrast, patients diagnosed with astrocytoma had a median PFS of 14.3 months (95% CI: 12.8 months to not reached) and a median OS of 17.0 months (95% CI: 10.6 months to not reached). Twenty-five patients (64.1%) experienced dermatological adverse events, and 30 (77.0%) experienced mild hematological adverse reactions related to chemoradiotherapy.Conclusion: The application of tumor-treating fields concurrent with post-surgery chemoradiotherapy is both safe and effective for treating patients with newly diagnosed WHO grade 4 gliomas, exhibiting only limited toxicity.

引用

页数：8

共 22 条

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