Microalgae-derived tocopherols: Biotechnological advances in production and its therapeutic potentials

被引:0
作者
Udaypal [1 ]
Goswami, Rahul Kumar [1 ]
Mehariya, Sanjeet [2 ,3 ]
Verma, Pradeep [1 ]
机构
[1] Cent Univ Rajasthan, Dept Microbiol, Bioproc & Bioenergy Lab BPBEL, Ajmer 305817, Rajasthan, India
[2] Qatar Univ, Coll Arts & Sci, Ctr Sustainable Dev, Algal Technol Program, Doha 2713, Qatar
[3] Manipal Univ, Fac Sci, Dept Biosci, Jaipur, Rajasthan, India
来源
SUSTAINABLE CHEMISTRY AND PHARMACY | 2024年 / 42卷
关键词
Therapeutic potentials; Functional foods; Antioxidants; Biorefinery; PRESSURIZED LIQUID EXTRACTION; MICROWAVE-ASSISTED EXTRACTION; ALPHA-TOCOPHEROL; VITAMIN-E; GAMMA-TOCOPHEROL; HOMOGENTISATE PHYTYLTRANSFERASE; COLON CARCINOGENESIS; LUNG TUMORIGENESIS; OXIDATIVE STRESS; DELTA-TOCOPHEROL;
D O I
10.1016/j.scp.2024.101791
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Tocopherols are antioxidants that have the potential to prevent chronic diseases. Currently, most tocopherols are produced via chemical synthesis that are often impure, less active, and have side effects. Natural tocopherols are only synthesized by photoautotrophs, and microalgae can accumulate a considerable amount of tocopherols up to 4 mg/g DW, in which alpha-tocopherol comprising up to 97% (similar to 3.88 mg/g DW) which is remarkably higher than other phototrophs. Microalgal tocopherol production is still limited to laboratory scale due to low biomass productivity, high cultivation cost, and low tocopherol recovery. This review aims to explore advanced biotechnological strategies such as optimizing cultivation conditions i.e., temperature, light intensity, and photoperiod, implementing nutrient stress, genetic manipulation, and producing valuable coproducts along tocopherols to overcome these challenges. The review provides a comprehensive comparison of advanced extraction technologies, including Solvent extraction, Ultrasoundassisted extraction, Microwave-assisted extraction, Matrix solid-phase dispersion, Pressurized liquid extraction, Supercritical fluid extraction, and Cell milking, and evaluates their efficiency and eco-friendliness in microalgal tocopherol extraction. This review discusses the potential therapeutic uses of microalgae-derived tocopherols in various diseases like cancer, Alzheimer's disease, cardiovascular disease, hyperglycemia, obesity, and skin aging. It also provides an update on their current market scenario and prospects.
引用
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页数:25
相关论文
共 233 条
[1]  
Abd El-BakyH H., 2004, Int J Agric Biol, V6, P49
[2]  
Fernández FGA, 2019, BIOMASS BIOF BIOCHEM, P551, DOI 10.1016/B978-0-444-64192-2.00021-4
[3]   Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases [J].
Aggarwal, Bharat B. ;
Sundaram, Chitra ;
Prasad, Seema ;
Kannappan, Ramaswamy .
BIOCHEMICAL PHARMACOLOGY, 2010, 80 (11) :1613-1631
[4]   Supercritical fluid extraction of seed oils-A short review of current trends [J].
Ahangari, Hossein ;
King, Jerry W. ;
Ehsani, Ali ;
Yousefi, Mohammad .
TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2021, 111 :249-260
[5]  
Ahmad T., 2019, J. Biol. Chem. Chron, V5, P114, DOI [10.33980/jbcc.2019.v05i01.019, DOI 10.33980/JBCC.2019.V05I01.019]
[6]   Natural anti-aging skincare: role and potential [J].
Ahmed, Idris Adewale ;
Mikail, Maryam Abimbola ;
Zamakshshari, Norhisam ;
Abdullah, Al-Shwyeh Hussah .
BIOGERONTOLOGY, 2020, 21 (03) :293-310
[7]   Vitamin E (α-, β plus γ- and δ-tocopherol) levels in plant oils [J].
Aksoz, Elif ;
Korkut, Oguzhan ;
Aksit, Dilek ;
Gokbulut, Cengiz .
FLAVOUR AND FRAGRANCE JOURNAL, 2020, 35 (05) :504-510
[8]   Over-expression of a cyanobacterial gene for 1-deoxy-D-xylulose-5-phosphate synthase in the chloroplast of Chlamydomonas reinhardtii perturbs chlorophyll: carotenoid ratios [J].
Al Hoqani, Umaima ;
Leon, Rosa ;
Purton, Saul .
JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2022, 34 (06)
[9]   Gingerol, a Natural Antioxidant, Attenuates Hyperglycemia and Downstream Complications [J].
Alharbi, Khalid Saad ;
Nadeem, Muhammad Shahid ;
Afzal, Obaid ;
Alzarea, Sami I. ;
Altamimi, Abdulmalik S. A. ;
Almalki, Waleed Hassan ;
Mubeen, Bismillah ;
Iftikhar, Saima ;
Shah, Luqman ;
Kazmi, Imran .
METABOLITES, 2022, 12 (12)
[10]   Tocopherol as plant protector: an overview of Tocopherol biosynthesis enzymes and their role as antioxidant and signaling molecules [J].
Ali, Essa ;
Hussain, Sayed ;
Hussain, Nazim ;
Kakar, Kaleem Ullah ;
Shah, Jawad Munawar ;
Zaidi, Syed Hassan Raza ;
Jan, Masood ;
Zhang, Kewei ;
Khan, Muhammad Ali ;
Imtiaz, Muhammad .
ACTA PHYSIOLOGIAE PLANTARUM, 2022, 44 (02)