A new diphenyl ether with insecticidal activity from the mangrove endophytic fungus Aspergillus sp. GXNU-DY2-12

被引：0
作者：
Tan, Meijing [1 ]
Ju, Shichao [1 ]
He, Fan [1 ]
Li, Wenjun [1 ]
Wei, Youquan [1 ]
Xu, Weifeng [1 ]
Yang, Ruiyun [1 ]
Huang, Xishan [1 ]
机构：
[1] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Key Lab Chem & Mol Engn Med Resources, Minist Educ China,Collaborat Innovat Ctr Guangxi E, Guilin 541004, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2025年
基金：
中国国家自然科学基金;
关键词：
Diphenyl ether; Aspergillus sp; endophytic fungus; acetylcholinesterase activity; insecticidal activity;
D O I：
10.1080/14786419.2025.2476201
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new diphenyl ether pseudopithoether C (1), and five known compounds (2-6) were purified from secondary metabolites of the Aspergillus sp. GXNU-DY2-12 cultured in the rice medium. The new structure was analysed by NMR, HR-ESI-MS, and X-ray single crystal diffractometer. Compound 1 showed potent acetylcholinesterase (AChE) - inhibiting activity and its IC50 value was 1.02 mu M. Notably, it demonstrated remarkable insecticidal efficacy against Diaphorina citri Kuwayama, achieving a mortality rate of 88% under standardised bioassay conditions.
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页数：9
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