Correlation between transforming growth factor-ß1 (TGF-β1) with premature atherosclerosis in type 1 diabetes

被引：0
作者：
Tjahjono, Harjoedi Adji [1 ,2 ]
Barlianto, Wisnu [3 ]
Handayani, Dian [4 ]
Kalim, Handono [5 ]
机构：
[1] Univ Brawijaya, Doctoral program Med Sci, Fac Med, Malang, Indonesia
[2] Saiful Anwar Hosp, Malang, Indonesia
[3] Univ Brawijaya, Fac Med, Pediat Dept, Malang, Indonesia
[4] Univ Brawijaya, Med Fac, Nutr Sci Program, Malang, Indonesia
[5] Univ Brawijaya, Fac Med, Dept Internal Med, Malang, Indonesia
来源：
ARYA ATHEROSCLEROSIS | 2024年 / 20卷 / 04期
关键词：
T1D; Premature Atherosclerosis; TGF-beta; 1; CIMT; FMD; INTIMA-MEDIA THICKNESS; CHILDREN;
D O I：
10.48305/arya.2024.11581.2125
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BACKGROUND: Type 1 diabetes (T1D) carries a significant risk of atherosclerosis as the main driver for cardiovascular events. Atherosclerosis is initiated by the activation of the endothelium by various risk factors through the inflammation process. The anti-inflammatory cytokine TGF-beta 1 may inhibit the development of atherosclerosis.<br /> METHODS: In a cross-sectional study, a total of 40 patients aged 14.5 +/- 3.16 years old with T1D and 40 healthy controls aged 14.7 +/- 0.99 years old were involved. Common carotid artery IMT (cIMT) was measured by real-time M-echocardiography mode (Affinity 50G Philips) and Flow Mediated Dilatation (FMD), using high-resolution ultrasonography and Doppler flow characteristics. The TGF-beta 1 level was measured by indirect ELISA at Saiful Anwar Hospital Laboratory.<br /> RESULTS: There were no differences in age, gender, Body Mass Index (BMI), duration of diabetes, renal function, or nutritional status between the T1D and healthy groups (p>0.05). A significant difference in cIMT was observed between the T1D group and the healthy group (0.567 +/- 0.87 mm vs. 0.387 +/- 0.57 mm, p = 0.000), FMD (7.17 +/- 3.98 mm vs. 11.22 +/- 5.48 mm, p = 0.000), and the level of TGF-beta 1 cytokine (39.83 +/- 13.51 vs. 73.67 +/- 15.34 pg/ml, p = 0.000). A significantly negative correlation between TGF-beta 1 and cIMT (p = 0.000; r = -0.685) and a significantly positive correlation between TGF-beta 1 and FMD (p = 0.000; r = +0.55) were found.<br /> CONCLUSION: Atherosclerosis is an inflammatory disease accelerated by diabetes. The inflammation process is more prominent in T1D patients. T1D patients show a decreased level of TGF-beta 1, increased measurement of cIMT (>0.5 mm), and a decreased measurement of FMD.
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页码：7 / 13
页数：7
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