Late-stage C-H trifluoroacetylation of quinoxaline-2(1H)-ones using masked trifluoroacyl reagents

被引：0
|
作者：
Shen, Yawei
Li, Yuan
Wang, Xia
Wei, Jiaoyan
Shen, Yafen
Wu, Lei [1 ]
Luo, Kai [1 ]
机构：
[1] Nanjing Agr Univ, Coll Sci, Jiangsu Key Lab Pesticide Sci, Nanjing 210095, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 07期
基金：
中国国家自然科学基金;
关键词：
TRIFLUOROMETHYL KETONES; BIOLOGICAL EVALUATION; METAL; QUINOXALIN-2(1H)-ONES; DESIGN; INHIBITORS; POTENT; FLUORINE; BOND; DERIVATIVES;
D O I：
10.1039/d4ob01945h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A strategy for trifluoroacetylation of quinoxaline-2(1H)-ones has been investigated. This strategy employs masked trifluoroacyl reagents to obtain trifluoroacetylated quinoxaline-2(1H)-ones under metal-, catalyst-, and light-free conditions. This approach is distinguished by its functional group compatibility and tolerance, as well as the simplicity of the experimental process, making it suitable for gram-scale synthesis.
引用
收藏
页码：1683 / 1688
页数：6
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