Late-stage C-H trifluoroacetylation of quinoxaline-2(1H)-ones using masked trifluoroacyl reagents

被引：0

作者：

Shen, Yawei

Li, Yuan

Wang, Xia

Wei, Jiaoyan

Shen, Yafen

Wu, Lei ^{[1
]}

Luo, Kai ^{[1
]}

机构：

[1] Nanjing Agr Univ, Coll Sci, Jiangsu Key Lab Pesticide Sci, Nanjing 210095, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 07期

基金：

中国国家自然科学基金;

关键词：

TRIFLUOROMETHYL KETONES; BIOLOGICAL EVALUATION; METAL; QUINOXALIN-2(1H)-ONES; DESIGN; INHIBITORS; POTENT; FLUORINE; BOND; DERIVATIVES;

D O I：

10.1039/d4ob01945h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A strategy for trifluoroacetylation of quinoxaline-2(1H)-ones has been investigated. This strategy employs masked trifluoroacyl reagents to obtain trifluoroacetylated quinoxaline-2(1H)-ones under metal-, catalyst-, and light-free conditions. This approach is distinguished by its functional group compatibility and tolerance, as well as the simplicity of the experimental process, making it suitable for gram-scale synthesis.

引用

页码：1683 / 1688

页数：6

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