The complete telomere-to-telomere sequence of a mouse genome

被引：1
|
作者：
Liu, Junli [1 ,2 ,3 ]
Li, Qilin [1 ,2 ,3 ]
Hu, Yixuan [1 ,2 ,3 ]
Yu, Yi [1 ,2 ,3 ]
Zheng, Kai [1 ,2 ,3 ]
Li, Dengfeng [1 ,2 ,3 ]
Qin, Lexin [1 ,2 ,3 ]
Yu, Xiaochun [1 ,2 ,3 ]
机构：
[1] Westlake Lab Life Sci & Biomed, Hangzhou, Zhejiang, Peoples R China
[2] Westlake Univ, Sch Life Sci, Hangzhou, Zhejiang, Peoples R China
[3] Westlake Inst Adv Study, Inst Basic Med Sci, Hangzhou, Zhejiang, Peoples R China
来源：
SCIENCE | 2024年 / 386卷 / 6726期
基金：
中国国家自然科学基金;
关键词：
EMBRYONIC STEM-CELLS; SATELLITE DNA; MINOR SATELLITE; CENTROMERE; ORGANIZATION; GENERATION; DRAFT; MICE;
D O I：
10.1126/science.adq8191
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The current reference genome of Mus musculus, GRCm39, has major gaps in both euchromatic and heterochromatic regions associated with repetitive sequences. In this work, we have sequenced and assembled the telomere-to-telomere genome of mouse haploid embryonic stem cells. The results reveal more than 7.7% of previously uncovered sequences of the mouse genome, including ribosomal DNA arrays and pericentromeric and subtelomeric regions, as well as an additional 140 genes predicted to be protein-coding. This study helps to address knowledge gaps in the mouse genome.
引用
收藏
页码：1141 / 1146
页数：6
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