Medicinal Herbal Extracts: Therapeutic Potential in Acute Lung Injury

被引：0

作者：

Lee, Jae-Won ^{[1
,2
]}

Lee, Hee Jae ^{[3
]}

Yun, Seok Han ^{[1
,4
]}

Lee, Juhyun ^{[1
]}

Kim, Hyueyun ^{[1
]}

Kang, Ha Yeong ^{[1
]}

Ahn, Kyung-Seop ^{[1
]}

Chun, Wanjoo ^{[3
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol KRIBB, Nat Med Res Ctr, Cheongju 28116, South Korea

[2] Univ Sci & Technol UST, Dept Biotechnol, Daejeon 34113, South Korea

[3] Kangwon Natl Univ, Coll Med, Dept Pharmacol, Chunchon 24341, South Korea

[4] Chungbuk Natl Univ, Coll Pharm, Cheongju 28160, South Korea

来源：

FUTURE PHARMACOLOGY | 2024年 / 4卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

acute lung injury; medicinal herbal extract; macrophages; cytokines; nuclear factor kappa B; NF-KAPPA-B; BILOBA LEAVES EXTRACT; D. DON BENN; EPITHELIAL-CELLS; ETHANOL EXTRACT; WATER EXTRACT; MURINE MODEL; IN-VITRO; LIPOPOLYSACCHARIDE; INFLAMMATION;

D O I：

10.3390/futurepharmacol4040037

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acute lung injury (ALI) is induced by pneumonia, sepsis and other conditions. The disease characteristics include severe lung inflammation, in which various cells, such as epithelial cells, macrophages, and neutrophils, play a pivotal role. Corticosteroids and antibiotics are used to treat ALI; however, they may have side effects. Cumulative data confirm that traditional herbal medicines exert therapeutic effects against endotoxin-induced inflammatory responses in both in vitro and in vivo ALI studies. This review briefly describes the anti-ALI effects of medicinal herbal extracts (MHEs) and their molecular mechanisms, especially focusing on Toll-like receptor 4/nuclear factor kappa B cell pathways, with a brief summary of in vitro and in vivo ALI experimental models. Thus, the present review highlights the excellent potential of MHEs for ALI therapy and prevention and may also be useful for the establishment of in vitro and in vivo ALI models.

引用

页码：700 / 715

页数：16