Major Publications in the Critical Care Pharmacotherapy Literature: 2023

被引：0

作者：

Murray, Brian ^{[1
]}

Athale, Janhavi ^{[2
]}

Balk, Robert A. ^{[3
,4
]}

Behal, Michael L. ^{[5
]}

Brown, Judah E. ^{[6
]}

Chanas, Tyler ^{[7
]}

Dumitru, Roxana ^{[6
]}

Gifford, Dalton C. ^{[8
]}

Hohlfelder, Benjamin ^{[9
]}

Jones, Honey M. ^{[10
]}

Makic, Mary Beth F. ^{[11
]}

Rausen, Michelle S. ^{[12
]}

Sacco, Alicia J. ^{[13
]}

Sines, Benjamin J. ^{[14
]}

Gurnani, Payal K. ^{[15
]}

机构：

[1] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Clin Pharm, Aurora, CO 80045 USA

[2] Mayo Clin Arizona, Dept Crit Care, Phoenix, AZ USA

[3] Rush Med Coll, Dept Internal Med, Div Pulm Crit Care & Sleep Med, Chicago, IL USA

[4] Rush Univ, Med Ctr, Chicago, IL USA

[5] Univ Tennessee, Med Ctr, Dept Pharm, Knoxville, TN USA

[6] Columbia Univ, Irving Med Ctr, NewYork Presbyterian Hosp, Dept Pharm, New York, NY USA

[7] ECU Hlth Med Ctr, Dept Pharm, Greenville, NC USA

[8] Univ Kentucky, Dept Vasc & Intervent Radiol, Lexington, KY USA

[9] Cleveland Clin, Dept Pharm, Cleveland, OH USA

[10] Univ N Carolina, Med Ctr, Dept Med, Div Pulm Dis & Crit Care Med, Chapel Hill, NC USA

[11] Univ Colorado, Coll Nursing, Anschutz Med Campus, Aurora, CO USA

[12] Mem Sloan Kettering Canc Ctr, Dept Resp Therapy, New York, NY USA

[13] Mayo Clin, Dept Pharm, Phoenix, AZ USA

[14] Univ North Carolina Chapel Hill, Dept Med, Div Pulm Dis & Crit Care Med, Chapel Hill, NC USA

[15] Houston Methodist Hosp, Dept Pharmcy, Houston, TX USA

来源：

CRITICAL CARE EXPLORATIONS | 2024年 / 6卷 / 10期

关键词：

critical bleeding; critical care; critically ill; pharmacotherapy; pneumonia; septic shock; VENTILATOR-ASSOCIATED PNEUMONIA; COMMUNITY-ACQUIRED PNEUMONIA; GOAL-DIRECTED THERAPY; SEVERE SEPSIS; SEPTIC SHOCK; CORTICOSTEROIDS; GUIDELINES; MANAGEMENT; INFUSION; TRENDS;

D O I：

10.1097/CCE.0000000000001162

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

OBJECTIVES:We aimed to summarize the most significant and impactful publications describing the pharmacotherapeutic care of critically ill patients in 2023.DATA SOURCES:PubMed/MEDLINE and the Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update.STUDY SELECTION:Randomized controlled trials and prospective studies of adult critically ill patients assessing a pharmacotherapeutic intervention and reporting clinical endpoints published between January 1, 2023, and December 31, 2023, were eligible for inclusion in this article.DATA EXTRACTION:Articles from a systematic search and the Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update were included. An a priori defined three-round modified Delphi process was employed to achieve consensus on the most impactful publications based on the following considerations: 1) overall contribution to scientific knowledge and 2) novelty to the literature.DATA SYNTHESIS:The systematic search and Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update returned a total of 1202 articles, of which 1164 were excluded. The remaining 38 articles underwent a three-round modified Delphi process. In each round, articles were independently scored based on overall contribution to scientific knowledge and novelty to the literature. Included articles are summarized and their impact discussed. Article topics included hydrocortisone for severe community-acquired pneumonia, inhaled amikacin for prevention of ventilator-associated pneumonia, methylene blue for septic shock, restrictive vs. liberal fluid management for sepsis-induced hypotension, andexanet alfa for major bleeding associated with factor Xa inhibitors, and early administration of four-factor prothrombin complex concentrate in patients with trauma at risk for massive transfusion.CONCLUSIONS:This review provides a summary and perspective on the potential impact of the most relevant articles in 2023 describing advances in the pharmacotherapeutic care of critically ill patients.

引用

页数：9

共 59 条

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Correa, Ricardo ;

Drover, Katherine ;

Esper, Annette M. ;

Gershengorn, Hayley B. ;

Hammond, Naomi E. ;

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Russell, James A. ;

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Holder, Andre L. ;

Kester, Alyssa N. ;

Kowalski, Kinsey R. ;

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Bronson, M. D. ;

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