Bioactive peptides derived from insect proteins: Preparation, biological activities, potential applications, and safety issues

Bioactive peptides are polypeptides with specific amino acid sequences that exhibit biological activities and health benefits. Insects have emerged as a sustainable source of proteins in human food and animal feed due to their efficient resource utilization, low environmental footprint, and good nutritional profile. Moreover, insectderived bioactive peptides (IBPs) offer potential applications in functional foods and pharmaceuticals due to their antioxidant, antimicrobial, antihypertensive, anti-inflammatory, antidiabetic, and anti-obesity activities. In this article, the isolation, purification, and properties of IBPs are reviewed, as well as their potential health benefits, commercial applications, and safety. Despite the growing interest in incorporating IBPs into food products, challenges regarding consumer acceptance, safety, and regulations still persist. Thus, there is a pressing need for further research in this area, as well as clarification of the regulatory framework, before the full potential of insects as a sustainable source of bioactive peptides for human consumption can be realized.